Ettore Cicinelli1, Maria Matteo2, Giueseppe Trojano1, Paola C Mitola1, Raffaele Tinelli3, Amerigo Vitagliano4, Francesco M Crupano1, Achiropita Lepera1, Giuseppe Miragliotta5, Leonardo Resta6. 1. 2nd Unit of Obstetrics and Gynecology, Department of Biomedical and Human Oncological Science (DIMO), University of Bari, Bari, Italy. 2. Institute of Obstetrics and Gynecology, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy. 3. Department of Obstetrics and Gynecology, Brindisi, Italy. 4. Department of Women and Children's Health, Unit of Gynecology and Obstetrics, University of Padua, Padua, Italy. 5. Institute of Microbiology, Department of Biomedical and Human Oncological Science (DIMO), University of Bari, Bari, Italy. 6. Institute of Pathology, Department of Biomedical and Human Oncological Science (DIMO), University of Bari, Bari, Italy.
Abstract
PROBLEM: The correlations between chronic endometritis and unexplained infertility are unexplored. METHOD OF STUDY: We performed a retrospective study on consecutive patients referred to our hysteroscopy service due to unexplained infertility. All women underwent endometrial sampling with histological and cultural examinations. If chronic endometritis was diagnosed, patients received antibiotic therapy, and chronic endometritis resolution was subsequently ascertained by histological examination. We aimed to estimate chronic endometritis prevalence and the effects of antibiotic therapy on spontaneous conception during the year following hysteroscopy. RESULTS: A total number of 95 women were included. Pooled prevalence of chronic endometritis was 56.8%. Antibiotic therapy resulted in chronic endometritis resolution in 82.3% of patients, while in 17.6% disease was persistent. Women with cured chronic endometritis showed higher pregnancy rate and live birth rate in comparison with both women with persistent disease and women without chronic endometritis diagnosis (pregnancy rate = 76.3% vs 20% vs 9.5%, P < .0001; live birth rate = 65.8% vs 6.6% vs 4.8%, P < .0001). CONCLUSION: Chronic endometritis is highly prevalent in patients with unexplained infertility. Diagnosis and treatment of chronic endometritis improve spontaneous pregnancy rate and live birth rate in such patients.
PROBLEM: The correlations between chronic endometritis and unexplained infertility are unexplored. METHOD OF STUDY: We performed a retrospective study on consecutive patients referred to our hysteroscopy service due to unexplained infertility. All women underwent endometrial sampling with histological and cultural examinations. If chronic endometritis was diagnosed, patients received antibiotic therapy, and chronic endometritis resolution was subsequently ascertained by histological examination. We aimed to estimate chronic endometritis prevalence and the effects of antibiotic therapy on spontaneous conception during the year following hysteroscopy. RESULTS: A total number of 95 women were included. Pooled prevalence of chronic endometritis was 56.8%. Antibiotic therapy resulted in chronic endometritis resolution in 82.3% of patients, while in 17.6% disease was persistent. Women with cured chronic endometritis showed higher pregnancy rate and live birth rate in comparison with both women with persistent disease and women without chronic endometritis diagnosis (pregnancy rate = 76.3% vs 20% vs 9.5%, P < .0001; live birth rate = 65.8% vs 6.6% vs 4.8%, P < .0001). CONCLUSION:Chronic endometritis is highly prevalent in patients with unexplained infertility. Diagnosis and treatment of chronic endometritis improve spontaneous pregnancy rate and live birth rate in such patients.
Authors: Maximilian Murtinger; Barbara Wirleitner; Dietmar Spitzer; Helena Bralo; Susanna Miglar; Maximilian Schuff Journal: Hum Reprod Open Date: 2022-06-07
Authors: Gianluca Raffaello Damiani; Giuseppe Muzzupapa; Mario Villa; Giuseppe Trojano; Vera Loizzi Journal: Gynecol Minim Invasive Ther Date: 2021-04-30
Authors: Nerea M Molina; Alberto Sola-Leyva; Maria Jose Saez-Lara; Julio Plaza-Diaz; Aleksandra Tubić-Pavlović; Barbara Romero; Ana Clavero; Juan Mozas-Moreno; Juan Fontes; Signe Altmäe Journal: Biomolecules Date: 2020-04-11