Combination chemotherapy for adrenal carcinoma: response in a 5 1/2-year-old male.

Adrenocortical carcinoma is an uncommon tumor of childhood, and systematic studies of therapeutic options are not available. Children with very large tumours have a poor outlook with surgery alone, so that other treatment should be considered, but the literature is unhelpful in suggesting what this should be. In the case reported here, combination chemotherapy, including cisplatinum, gave a well-documented good partial response, suggesting a possible role for adjuvant chemotherapy using such a drug combination.