Qingming Liu1, Ying Shen2, Xinyu Cao3, Yongqiang Li2, Yijiang Chen4, Wei Yang5, Ti-Fei Yuan1,6,7,8. 1. School of Psychology, Nanjing Normal University, Nanjing, China. 2. Rehabilitation Medicine Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 3. Da Lian Shan Institute of Addiction Rehabilitation, Nanjing, China. 4. Mental Health Education Center, Nanjing Tech University, Nanjing, China. 5. The Second Hospital of Jilin University, Jilin, China. 6. Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China. 7. Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. 8. Shanghai Mental Health Center, Shanghai Jiaotong University of Medicine, Shanghai, China.
Abstract
BACKGROUND AND OBJECTIVES: The study is to investigate if left or right dorsolateral prefrontal cortex is important in modulating the craving to drug related cues. METHODS: The present investigation examined different combinations between left/right and high/low frequency rTMS on cue induced craving to methamphetamine, with active sham rTMS on P3 region on a total of 50 subjects. RESULTS: The results showed that either at left or right side, both high and low frequency rTMS are effective in decreasing the cue induced craving to methamphetamine. DISCUSSION AND CONCLUSIONS: In conclusion, bilateral frontal hemispheres are effective in modulating the cue induced craving to methamphetamine with rTMS. SCIENTIFIC SIGNIFICANCE: TMS targeting prefrontal cortex is effective for craving modulation; however the mechanism is more than potentiation or depression of single brain region. (Am J Addict 2017;26:776-779).
RCT Entities:
BACKGROUND AND OBJECTIVES: The study is to investigate if left or right dorsolateral prefrontal cortex is important in modulating the craving to drug related cues. METHODS: The present investigation examined different combinations between left/right and high/low frequency rTMS on cue induced craving to methamphetamine, with active sham rTMS on P3 region on a total of 50 subjects. RESULTS: The results showed that either at left or right side, both high and low frequency rTMS are effective in decreasing the cue induced craving to methamphetamine. DISCUSSION AND CONCLUSIONS: In conclusion, bilateral frontal hemispheres are effective in modulating the cue induced craving to methamphetamine with rTMS. SCIENTIFIC SIGNIFICANCE: TMS targeting prefrontal cortex is effective for craving modulation; however the mechanism is more than potentiation or depression of single brain region. (Am J Addict 2017;26:776-779).
Authors: Hamed Ekhtiari; Hosna Tavakoli; Giovanni Addolorato; Chris Baeken; Antonello Bonci; Salvatore Campanella; Luis Castelo-Branco; Gaëlle Challet-Bouju; Vincent P Clark; Eric Claus; Pinhas N Dannon; Alessandra Del Felice; Tess den Uyl; Marco Diana; Massimo di Giannantonio; John R Fedota; Paul Fitzgerald; Luigi Gallimberti; Marie Grall-Bronnec; Sarah C Herremans; Martin J Herrmann; Asif Jamil; Eman Khedr; Christos Kouimtsidis; Karolina Kozak; Evgeny Krupitsky; Claus Lamm; William V Lechner; Graziella Madeo; Nastaran Malmir; Giovanni Martinotti; William M McDonald; Chiara Montemitro; Ester M Nakamura-Palacios; Mohammad Nasehi; Xavier Noël; Masoud Nosratabadi; Martin Paulus; Mauro Pettorruso; Basant Pradhan; Samir K Praharaj; Haley Rafferty; Gregory Sahlem; Betty Jo Salmeron; Anne Sauvaget; Renée S Schluter; Carmen Sergiou; Alireza Shahbabaie; Christine Sheffer; Primavera A Spagnolo; Vaughn R Steele; Ti-Fei Yuan; Josanne D M van Dongen; Vincent Van Waes; Ganesan Venkatasubramanian; Antonio Verdejo-García; Ilse Verveer; Justine W Welsh; Michael J Wesley; Katie Witkiewitz; Fatemeh Yavari; Mohammad-Reza Zarrindast; Laurie Zawertailo; Xiaochu Zhang; Yoon-Hee Cha; Tony P George; Flavio Frohlich; Anna E Goudriaan; Shirley Fecteau; Stacey B Daughters; Elliot A Stein; Felipe Fregni; Michael A Nitsche; Abraham Zangen; Marom Bikson; Colleen A Hanlon Journal: Neurosci Biobehav Rev Date: 2019-07-02 Impact factor: 8.989