Carlo Fornaini1,2, Luigi Cella1, Aldo Oppici1, Anna Parlatore3, Fabio Clini1, Matteo Fontana1, Giuseppe Lagori1, Elisabetta Merigo1,2. 1. Odontostomatology and Maxillo-Facial Surgery Unit - Special care dentistry "Guglielmo da Saliceto" Hospital - Piacenza - Italy. 2. UFR Odontologie - Université de Nice "Sophia Antipolis" - Nice - France. 3. Immunohematology and Transfusion Medicine "Guglielmo da Saliceto Hospital - Piacenza - Italy.
Abstract
AIMS: The appropriate management of Medication-Related OsteoNecrosis of the Jaw (MRONJ) is still a challenge for dentists and oral surgeons and in these last years high-technology instruments have been proposed at the different steps of interventions, also combined with promoters of tissue repair.The aim of this report is to show the advantages of a combined approach (laser and PRP) for the treatment of MRONJ. METHODS: It is described the case of a patient positive for MRONJ observed at the Odontostomatology and Maxillo-Facial Surgery Unit of the Hospital of Piacenza where surgical approach was performed by using different devices: Er:YAG laser (2940 nm) to remove and vaporize necrotic hard tissue until bleeding bone; Platelet-Rich Plasma (PRP) to stimulate hard and soft tissue healing; diode laser (808 nm) to biostimulate the surgical site. RESULTS: At the time of suture removal, wound closure was observed and the complete healing of the MRONJ site was observed for the 2 years follow up. CONCLUSION: This case may suggest that this kind of combined approach during all the steps of MRONJ treatment allows to perform a faster and less invasive surgery with a more comfortable postoperative healing process and it represents an innovative approach in this severe adverse event.
AIMS: The appropriate management of Medication-Related OsteoNecrosis of the Jaw (MRONJ) is still a challenge for dentists and oral surgeons and in these last years high-technology instruments have been proposed at the different steps of interventions, also combined with promoters of tissue repair.The aim of this report is to show the advantages of a combined approach (laser and PRP) for the treatment of MRONJ. METHODS: It is described the case of a patient positive for MRONJ observed at the Odontostomatology and Maxillo-Facial Surgery Unit of the Hospital of Piacenza where surgical approach was performed by using different devices: Er:YAG laser (2940 nm) to remove and vaporize necrotic hard tissue until bleeding bone; Platelet-Rich Plasma (PRP) to stimulate hard and soft tissue healing; diode laser (808 nm) to biostimulate the surgical site. RESULTS: At the time of suture removal, wound closure was observed and the complete healing of the MRONJ site was observed for the 2 years follow up. CONCLUSION: This case may suggest that this kind of combined approach during all the steps of MRONJ treatment allows to perform a faster and less invasive surgery with a more comfortable postoperative healing process and it represents an innovative approach in this severe adverse event.
Entities:
Keywords:
Er:YAG laser; Laser; Medication-Related Osteonecrosis of the Jaws; Photobiomodulation; Platelet-Rich Plasma
Authors: R E Marx; E R Carlson; R M Eichstaedt; S R Schimmele; J E Strauss; K R Georgeff Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 1998-06
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Authors: Rodolfo Mauceri; Vera Panzarella; Laura Maniscalco; Alberto Bedogni; Maria Ester Licata; Antonino Albanese; Francesca Toia; Enzo Maria Giuseppe Cumbo; Giuseppina Mazzola; Olga Di Fede; Giuseppina Campisi Journal: Biomed Res Int Date: 2018-08-19 Impact factor: 3.411