Literature DB >> 29133191

Galectin-3: mediator of microglia responses in injured brain.

Reza Rahimian1, Louis-Charles Béland1, Jasna Kriz2.   

Abstract

Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 29133191     DOI： 10.1016/j.drudis.2017.11.004

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  27 in total

1.  Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP.

Authors:  Qianqian Zhang; Wenge Li; Yanting Zhu; Qingting Wang; Cui Zhai; Wenhua Shi; Wei Feng; Jian Wang; Xin Yan; Limin Chai; Yuqian Chen; Cong Li; Pengtao Liu; Manxiang Li
Journal:  Mol Cell Biochem       Date:  2021-04-02       Impact factor: 3.396

2.  Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury.

Authors:  Leilei Gong; Yun Gu; Xiaoxiao Han; Chengcheng Luan; Chang Liu; Xinghui Wang; Yufeng Sun; Mengru Zheng; Mengya Fang; Shuhai Yang; Lai Xu; Hualin Sun; Bin Yu; Xiaosong Gu; Songlin Zhou
Journal:  Neurosci Bull       Date:  2022-07-05       Impact factor: 5.203

Review 3.  Neuroinflammation and galectins: a key relationship in neurodegenerative diseases.

Authors:  Eleazar Ramírez Hernández; Beatriz Alanis Olvera; Daniela Carmona González; Oscar Guerrero Marín; Denisse Pantoja Mercado; Lucero Valencia Gil; Luis F Hernández-Zimbrón; José Luis Sánchez Salgado; I Daniel Limón; Edgar Zenteno
Journal:  Glycoconj J       Date:  2022-06-02       Impact factor: 3.009

4.  Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia.

Authors:  Yu Cui; Nan-Nan Zhang; Dan Wang; Wei-Hong Meng; Hui-Sheng Chen
Journal:  J Inflamm Res       Date:  2022-06-09

Review 5.  Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder.

Authors:  Reza Rahimian; Claudia Belliveau; Rebecca Chen; Naguib Mechawar
Journal:  Front Psychiatry       Date:  2022-06-16       Impact factor: 5.435

Review 6.  Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration.

Authors:  Mar Puigdellívol; David H Allendorf; Guy C Brown
Journal:  Front Cell Neurosci       Date:  2020-06-09       Impact factor: 5.505

7.  Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia.

Authors:  Lianne J Trigiani; Jessika Royea; Xin-Kang Tong; Edith Hamel
Journal:  FASEB J       Date:  2019-09-26       Impact factor: 5.834

Review 8.  Galectins in the Pathogenesis of Common Retinal Disease.

Authors:  Bruna Caridi; Dilyana Doncheva; Sobha Sivaprasad; Patric Turowski
Journal:  Front Pharmacol       Date:  2021-05-17       Impact factor: 5.810

9.  Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin-3 level.

Authors:  Shizhan Ma; Shangbin Li; Renjun Lv; Xunyao Hou; Shanjing Nie; Qingqing Yin
Journal:  J Diabetes Investig       Date:  2020-04-28       Impact factor: 4.232

Review 10.  Galectin-3-Mediated Glial Crosstalk Drives Oligodendrocyte Differentiation and (Re)myelination.

Authors:  Laura Thomas; Laura Andrea Pasquini
Journal:  Front Cell Neurosci       Date:  2018-09-12       Impact factor: 5.505
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.