| Literature DB >> 2913305 |
G D Diana1, D Cutcliffe, R C Oglesby, M J Otto, J P Mallamo, V Akullian, M A McKinlay.
Abstract
A number of 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes. A QSAR study revealed that the mean MIC (MIC) against five rhinovirus serotypes correlated well with log P. The 2,6-dichloro analogue, 15, was highly effective in vitro against rhinoviruses with an MIC80 of 0.3 microM, as well as against several enteroviruses, and was also effective in preventing paralysis in mice infected with coxsackievirus A-9.Entities:
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Year: 1989 PMID： 2913305 DOI： 10.1021/jm00122a027
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446