| Literature DB >> 29132973 |
Isabel Heyde1, Jana-Thabea Kiehn1, Henrik Oster2.
Abstract
The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.Entities:
Keywords: Circadian clock; Clock gene; Metabolism; Physiology; Sleep deprivation
Mesh:
Year: 2017 PMID: 29132973 DOI: 10.1016/j.freeradbiomed.2017.11.003
Source DB: PubMed Journal: Free Radic Biol Med ISSN: 0891-5849 Impact factor: 7.376