Anne A E Thorup1, Thomas Munk Laursen2, Trine Munk-Olsen3, Anne Ranning4, Preben Bo Mortensen5, Kerstin J Plessen6, Merete Nordentoft7. 1. Child and Adolescent Mental Health Center, Capital Region of Denmark, Denmark; iPsych - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Denmark. Electronic address: Anne.Amalie.Elgaard.Thorup@regionh.dk. 2. National Center for Register-Based Research, Aarhus University, Denmark; iPsych - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark. Electronic address: tml@econ.au.dk. 3. National Center for Register-Based Research, Aarhus University, Denmark; iPsych - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark. Electronic address: tmo@econ.au.dk. 4. Reseach Unit at Mental Health Center Copenhagen, Capital Region of Denmark, Denmark; iPsych - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark. Electronic address: Anne.Ranning@regionh.dk. 5. National Center for Register-Based Research, Aarhus University, Denmark; Cirrau - Centre for Integrated Register-based Research at Aarhus University, Denmark. Electronic address: pbm@econ.au.dk. 6. Child and Adolescent Mental Health Center, Capital Region of Denmark, Denmark; iPsych - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Denmark. Electronic address: Kerstin.Jessica.Plessen@regionh.dk. 7. Reseach Unit at Mental Health Center Copenhagen, Capital Region of Denmark, Denmark; iPsych - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Denmark. Electronic address: Merete.Nordentoft@dadlnet.dk.
Abstract
BACKGROUND: Offspring of parents with severe mental illness (SMI: schizophrenia, bipolar disorder or major depressive disorder) have an increased risk of developing mental disorder themselves. In childhood they may have neurodevelopmental delays, cognitive deficits and social adversities. We aimed to investigate if these individuals are more at risk of being diagnosed with a mental disorder during childhood/adolescence in a national sample. METHODS: By linking Danish registers we established a cohort consisting of all persons born to parents with SMI with those born to parents without SMI serving as a reference group. Incidence rate ratios (IRRs) for offspring diagnosed with a mental disorder by parental mental disorder were calculated. RESULTS: Offspring of parents with SMI showed increased IRR for all diagnoses of child and adolescent mental disorders compared to the reference group. Offspring of mothers with schizophrenia had IRR of 2.60 (CI: 2.50-2.70, N=2550) of having any diagnoses, for children of fathers with schizophrenia IRR was 2.06 (CI: 1.97-2.16, N=1901) and for offspring of two parents with schizophrenia IRR was 4.57 (CI: 3.94-5.31, N=175). For individuals with a mother with bipolar disorder the IRR was 2.29 (CI: 2.09-2.50, N=502), with a father 1.77 (CI: 1.74-1.87, N=320), whereas the IRR was 2.96 (CI: 2.63-3.34, N=264) if both parents had unipolar depression. DISCUSSION: Offspring of parents with a SMI have a higher risk of being diagnosed with any child and adolescent mental disorder. The IRRs for all diagnoses during childhood were increased by a factor 2-4. Having two ill parents increased the IRR.
BACKGROUND: Offspring of parents with severe mental illness (SMI: schizophrenia, bipolar disorder or major depressive disorder) have an increased risk of developing mental disorder themselves. In childhood they may have neurodevelopmental delays, cognitive deficits and social adversities. We aimed to investigate if these individuals are more at risk of being diagnosed with a mental disorder during childhood/adolescence in a national sample. METHODS: By linking Danish registers we established a cohort consisting of all persons born to parents with SMI with those born to parents without SMI serving as a reference group. Incidence rate ratios (IRRs) for offspring diagnosed with a mental disorder by parental mental disorder were calculated. RESULTS: Offspring of parents with SMI showed increased IRR for all diagnoses of child and adolescent mental disorders compared to the reference group. Offspring of mothers with schizophrenia had IRR of 2.60 (CI: 2.50-2.70, N=2550) of having any diagnoses, for children of fathers with schizophreniaIRR was 2.06 (CI: 1.97-2.16, N=1901) and for offspring of two parents with schizophreniaIRR was 4.57 (CI: 3.94-5.31, N=175). For individuals with a mother with bipolar disorder the IRR was 2.29 (CI: 2.09-2.50, N=502), with a father 1.77 (CI: 1.74-1.87, N=320), whereas the IRR was 2.96 (CI: 2.63-3.34, N=264) if both parents had unipolar depression. DISCUSSION: Offspring of parents with a SMI have a higher risk of being diagnosed with any child and adolescent mental disorder. The IRRs for all diagnoses during childhood were increased by a factor 2-4. Having two ill parents increased the IRR.
Authors: Sanne Ellegård Jørgensen; Susan I Michelsen; Anette Andersen; Janne S Tolstrup; Lau C Thygesen Journal: Clin Epidemiol Date: 2021-04-01 Impact factor: 4.790
Authors: Christian D G Stoltenberg; Lars R Nissen; Anni B S Nielsen; Mia S Vedtofte; Jacob L Marott; Finn Gyntelberg; Bernadette Guldager Journal: J Trauma Stress Date: 2020-03-29