Literature DB >> 29131575

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.

Ashleigh S Paparella1, Kwang Jun Lee2, Andrew J Hayes1, Jiage Feng2,3, Zikai Feng1, Danielle Cini4, Sonali Deshmukh1, Grant W Booker1, Matthew C J Wilce4, Steven W Polyak1, Andrew D Abell2,3.   

Abstract

We report the synthesis and evaluation of 5-halogenated-1,2,3-triazoles as inhibitors of biotin protein ligase from Staphylococcus aureus. The halogenated compounds exhibit significantly improved antibacterial activity over their nonhalogenated counterparts. Importantly, the 5-fluoro-1,2,3-triazole compound 4c displays antibacterial activity against S. aureus ATCC49775 with a minimum inhibitory concentration (MIC) of 8 μg/mL.

Entities:  

Keywords:  Staphylococcus aureus; antibiotic; biotin protein ligase; enzyme inhibitor

Mesh：

Substances：

Year:  2017        PMID： 29131575     DOI： 10.1021/acsinfecdis.7b00134

Source DB:  PubMed          Journal:  ACS Infect Dis        ISSN： 2373-8227            Impact factor:   5.084


  3 in total

1.  Native mass spectrometry identifies an alternative DNA-binding pathway for BirA from Staphylococcus aureus.

Authors:  Jiulia Satiaputra; Louise M Sternicki; Andrew J Hayes; Tara L Pukala; Grant W Booker; Keith E Shearwin; Steven W Polyak
Journal:  Sci Rep       Date:  2019-02-26       Impact factor: 4.379

2.  Cinnamaldehyde derivatives act as antimicrobial agents against Acinetobacter baumannii through the inhibition of cell division.

Authors:  Wern Chern Chai; Jonathan J Whittall; Steven W Polyak; Klyie Foo; Xin Li; Cameron J Dutschke; Abiodun D Ogunniyi; Shutao Ma; Matthew J Sykes; Susan J Semple; Henrietta Venter
Journal:  Front Microbiol       Date:  2022-08-29       Impact factor: 6.064

3.  Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase.

Authors:  Andrew J Hayes; Jiulia Satiaputra; Louise M Sternicki; Ashleigh S Paparella; Zikai Feng; Kwang J Lee; Beatriz Blanco- Rodriguez; William Tieu; Bart A Eijkelkamp; Keith E Shearwin; Tara L Pukala; Andrew D Abell; Grant W Booker; Steven W Polyak
Journal:  Antibiotics (Basel)       Date:  2020-04-06
  3 in total

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