Erez Shmuel Davidi1, Tamar Dreifuss2, Menachem Motiei2, Eliezer Shai3, Dimitri Bragilovski4, Leon Lubimov4, Marc Jose Jonathan Kindler4, Aron Popovtzer4,5, Jeremy Don3, Rachela Popovtzer2. 1. Department of Otolaryngology Head and Neck Surgery, Kaplan Medical Center, Rehovot, Israel. 2. Faculty of Engineering and the Institutes of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel. 3. The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. 4. Head and Neck Cancer Radiation Clinic, Institute of Oncology, Davidoff Cancer Center, Rabin Medical Center, Petah Tiqwa, Israel. 5. Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Israel.
Abstract
BACKGROUND: The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer. METHODS: We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities. RESULTS: The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities. CONCLUSION: Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.
BACKGROUND: The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer. METHODS: We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities. RESULTS: The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities. CONCLUSION: Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.
Authors: Olga Klaudia Szewczyk; Piotr Roszczenko; Robert Czarnomysy; Anna Bielawska; Krzysztof Bielawski Journal: Int J Mol Sci Date: 2022-06-15 Impact factor: 6.208