Literature DB >> 29130415

Mechanisms and function of autophagy in intestinal disease.

Kara G Lassen1,2, Ramnik J Xavier1,2,3.   

Abstract

The discovery of numerous genetic variants in the human genome that are associated with inflammatory bowel disease (IBD) has revealed critical pathways that play important roles in intestinal homeostasis. These genetic studies have identified a critical role for macroautophagy/autophagy and more recently, lysosomal function, in maintaining the intestinal barrier and mucosal homeostasis. This review highlights recent work on the functional characterization of IBD-associated human genetic variants in cell type-specific functions for autophagy.

Entities:  

Keywords:  ATG16L1; Crohn disease; GPR65; IBD; autophagy; inflammation; lysosomal dysfunction; mitophagy

Mesh：

Substances：

Year:  2018        PMID： 29130415      PMCID： PMC5902220          DOI： 10.1080/15548627.2017.1389358

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  61 in total

1.  Commensal bacteria direct selective cargo sorting to promote symbiosis.

Authors:  Qin Zhang; Ying Pan; Ruiqing Yan; Benhua Zeng; Haifang Wang; Xinwen Zhang; Wenxia Li; Hong Wei; Zhihua Liu
Journal:  Nat Immunol       Date:  2015-08-03       Impact factor: 25.606

2.  The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.

Authors:  Michael I Whang; Rita M Tavares; Daniel I Benjamin; Michael G Kattah; Rommel Advincula; Daniel K Nomura; Jayanta Debnath; Barbara A Malynn; Averil Ma
Journal:  Immunity       Date:  2017-03-14       Impact factor: 31.745

3.  The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients.

Authors:  Mehdi Sadaghian Sadabad; Anouk Regeling; Marcus C de Goffau; Tjasso Blokzijl; Rinse K Weersma; John Penders; Klaas Nico Faber; Hermie J M Harmsen; Gerard Dijkstra
Journal:  Gut       Date:  2014-09-24       Impact factor: 23.059

4.  Regulated in development and DNA damage responses 1 (REDD1) links stress with IL-1β-mediated familial Mediterranean fever attack through autophagy-driven neutrophil extracellular traps.

Authors:  Panagiotis Skendros; Akrivi Chrysanthopoulou; François Rousset; Konstantinos Kambas; Athanasios Arampatzioglou; Alexandros Mitsios; Veronique Bocly; Theocharis Konstantinidis; Philippe Pellet; Iliana Angelidou; Eirini Apostolidou; Dimitrios Ritis; Victoria Tsironidou; Sotiris Galtsidis; Charalampos Papagoras; Dimitrios Stakos; Georgios Kouklakis; Vasiliki Dalla; Maria Koffa; Ioannis Mitroulis; Ioannis Theodorou; Konstantinos Ritis
Journal:  J Allergy Clin Immunol       Date:  2017-03-23       Impact factor: 10.793

5.  Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.

Authors:  Kara G Lassen; Craig I McKenzie; Muriel Mari; Tatsuro Murano; Jakob Begun; Leigh A Baxt; Gautam Goel; Eduardo J Villablanca; Szu-Yu Kuo; Hailiang Huang; Laurence Macia; Atul K Bhan; Marcel Batten; Mark J Daly; Fulvio Reggiori; Charles R Mackay; Ramnik J Xavier
Journal:  Immunity       Date:  2016-06-07       Impact factor: 31.745

6.  Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Authors:  Kara G Lassen; Petric Kuballa; Kara L Conway; Khushbu K Patel; Christine E Becker; Joanna M Peloquin; Eduardo J Villablanca; Jason M Norman; Ta-Chiang Liu; Robert J Heath; Morgan L Becker; Lola Fagbami; Heiko Horn; Johnathan Mercer; Omer H Yilmaz; Jacob D Jaffe; Alykhan F Shamji; Atul K Bhan; Steven A Carr; Mark J Daly; Herbert W Virgin; Stuart L Schreiber; Thaddeus S Stappenbeck; Ramnik J Xavier
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-12       Impact factor: 11.205

7.  Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.

Authors:  Hong Zhang; Libo Zheng; Dermot P B McGovern; Ariel M Hamill; Ryan Ichikawa; Yoshitake Kanazawa; Justin Luu; Kotaro Kumagai; Marianne Cilluffo; Masayuki Fukata; Stephan R Targan; David M Underhill; Xiaolan Zhang; David Q Shih
Journal:  J Immunol       Date:  2017-01-27       Impact factor: 5.426

8.  mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.

Authors:  Claudia Manzoni; Adamantios Mamais; Dorien A Roosen; Sybille Dihanich; Marc P M Soutar; Helene Plun-Favreau; Rina Bandopadhyay; John Hardy; Sharon A Tooze; Mark R Cookson; Patrick A Lewis
Journal:  Sci Rep       Date:  2016-10-12       Impact factor: 4.379

9.  Paneth cells as a site of origin for intestinal inflammation.

Authors:  Timon E Adolph; Michal F Tomczak; Lukas Niederreiter; Hyun-Jeong Ko; Janne Böck; Eduardo Martinez-Naves; Jonathan N Glickman; Markus Tschurtschenthaler; John Hartwig; Shuhei Hosomi; Magdalena B Flak; Jennifer L Cusick; Kenji Kohno; Takao Iwawaki; Susanne Billmann-Born; Tim Raine; Richa Bharti; Ralph Lucius; Mi-Na Kweon; Stefan J Marciniak; Augustine Choi; Susan J Hagen; Stefan Schreiber; Philip Rosenstiel; Arthur Kaser; Richard S Blumberg
Journal:  Nature       Date:  2013-10-02       Impact factor: 49.962

10.  Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

Authors:  Tobias Schwerd; Sumeet Pandey; Huei-Ting Yang; Katrin Bagola; Elisabeth Jameson; Jonathan Jung; Robin H Lachmann; Neil Shah; Smita Y Patel; Claire Booth; Heiko Runz; Gesche Düker; Ruth Bettels; Marianne Rohrbach; Subra Kugathasan; Helen Chapel; Satish Keshav; Abdul Elkadri; Nick Platt; Alexio M Muise; Sibylle Koletzko; Ramnik J Xavier; Thorsten Marquardt; Fiona Powrie; James E Wraith; Mads Gyrd-Hansen; Frances M Platt; Holm H Uhlig
Journal:  Gut       Date:  2016-03-07       Impact factor: 23.059
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  24 in total

1.  SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1α.

Authors:  Chao Zhou; Liangzi Li; Teming Li; Lihua Sun; Jiuheng Yin; Haidi Guan; Liucan Wang; Hongbing Zhu; Peng Xu; Xin Fan; Baifa Sheng; Weidong Xiao; Yuan Qiu; Hua Yang
Journal:  J Mol Med (Berl)       Date:  2020-07-22       Impact factor: 4.599

2.  A non-canonical autophagy-dependent role of the ATG16L1T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence.

Authors:  Caihong Wang; Kyle A Bauckman; Adam S B Ross; Jane W Symington; Marianne M Ligon; Gael Scholtes; Akhil Kumar; Hao-Wei Chang; Joy Twentyman; Bisiayo E Fashemi; Ramnik J Xavier; Indira U Mysorekar
Journal:  Autophagy       Date:  2018-11-08       Impact factor: 16.016

3.  Cryptosporidium parvum infection induces autophagy in intestinal epithelial cells.

Authors:  Shubha Priyamvada; Dulari Jayawardena; Jeet Bhalala; Anoop Kumar; Arivarasu N Anbazhagan; Waddah A Alrefai; Alip Borthakur; Pradeep K Dudeja
Journal:  Cell Microbiol       Date:  2020-12-22       Impact factor: 3.715

Review 4.  Emerging views of OPTN (optineurin) function in the autophagic process associated with disease.

Authors:  Yueping Qiu; Jincheng Wang; Hui Li; Bo Yang; Jiajia Wang; Qiaojun He; Qinjie Weng
Journal:  Autophagy       Date:  2021-04-13       Impact factor: 16.016

Review 5.  How autophagy controls the intestinal epithelial barrier.

Authors:  Elisabeth G Foerster; Tapas Mukherjee; Liliane Cabral-Fernandes; Juliana D B Rocha; Stephen E Girardin; Dana J Philpott
Journal:  Autophagy       Date:  2021-04-27       Impact factor: 16.016

Review 6.  Exercise-mediated regulation of autophagy in the cardiovascular system.

Authors:  Lijun Wang; Jiaqi Wang; Dragos Cretoiu; Guoping Li; Junjie Xiao
Journal:  J Sport Health Sci       Date:  2019-10-15       Impact factor: 7.179

Review 7.  Self-eating and Heart: The Emerging Roles of Autophagy in Calcific Aortic Valve Disease.

Authors:  Yunlong Fan; Jiakang Shao; Shixiong Wei; Chao Song; Yanan Li; Shengli Jiang
Journal:  Aging Dis       Date:  2021-08-01       Impact factor: 6.745

8.  Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation.

Authors:  Seth D Merkley; Samuel M Goodfellow; Yan Guo; Zoe E R Wilton; Janie R Byrum; Kurt C Schwalm; Darrell L Dinwiddie; Rama R Gullapalli; Vojo Deretic; Anthony Jimenez Hernandez; Steven B Bradfute; Julie G In; Eliseo F Castillo
Journal:  J Crohns Colitis       Date:  2022-02-23       Impact factor: 10.020

9.  Radiotherapy Induces Intestinal Barrier Dysfunction by Inhibiting Autophagy.

Authors:  Wei Qu; Lijin Zhang; Jinfang Ao
Journal:  ACS Omega       Date:  2020-05-27

10.  miRNA-182/Deptor/mTOR axis regulates autophagy to reduce intestinal ischaemia/reperfusion injury.

Authors:  Yunsheng Li; Yanhua Luo; Baochuan Li; Lijun Niu; Jiaxin Liu; Xiaoyun Duan
Journal:  J Cell Mol Med       Date:  2020-06-08       Impact factor: 5.310
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