Literature DB >> 29129748

Cellular calcium signaling in the aging brain.

Remya Chandran1, Mantosh Kumar2, Lakshmi Kesavan2, Reena Sarah Jacob2, Sowmya Gunasekaran2, Sethu Lakshmi2, C Sadasivan1, R V Omkumar3.   

Abstract

Aging in the biological system is an irreversible process. In the initial stages of lifespan aging improves survival skills of an organism while in the later stages aging reduce the survival skills. Aging is associated with changes in several cellular and molecular functions among which calcium signaling is a prominent one. Calcium signaling is essential for many vital functions of the brain and even minor impairments in calcium signaling can lead to deleterious consequences including neuronal death. Calcium signaling proteins are pursued as promising drug targets for many aging related diseases. This review attempts to summarize changes in calcium signaling in the brain as a result of aging.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Aging; Aging associated neurodegenerative disease; Calcium channels; Calcium signaling; Excitotoxicity; Neuronal calcium homeostasis; Oxidative stress

Mesh：

Year:  2017        PMID： 29129748     DOI： 10.1016/j.jchemneu.2017.11.008

Source DB:  PubMed          Journal:  J Chem Neuroanat        ISSN： 0891-0618            Impact factor:   3.052


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