Literature DB >> 2912899

Antibodies raised against synthetic peptides from the Arg-Gly-Asp-containing region of the Leishmania surface protein gp63 cross-react with human C3 and interfere with gp63-mediated binding to macrophages.

D G Russell1, P Talamas-Rohana, J Zelechowski.   

Abstract

The Leishmania surface glycoprotein gp63 binds to complement receptor type 3 on the macrophage surface. Antibody raised against a synthetic peptide containing the Arg-Gly-Asp region of the amino acid sequence of gp63 recognizes both gp63 and the alpha-chain of human C3. Monovalent Fab fragments from this antibody block gp63-mediated binding to macrophages.

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Year:  1989        PMID： 2912899      PMCID： PMC313143          DOI： 10.1128/iai.57.2.630-632.1989

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Role of the RGD sequence in parasite adhesion to host cells.

Authors:  M A Ouaissi
Journal:  Parasitol Today       Date:  1988-06

2.  Monoclonal antibody affinity purification of a Leishmania membrane glycoprotein and its inhibition of leishmania-macrophage binding.

Authors:  C S Chang; K P Chang
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

3.  The major surface protein of Leishmania promastigotes is a fibronectin-like molecule.

Authors:  F S Rizvi; M A Ouaissi; B Marty; F Santoro; A Capron
Journal:  Eur J Immunol       Date:  1988-03       Impact factor: 5.532

4.  Attachment of plasma membrane vesicles of human macrophages to Leishmania tropica promastigotes.

Authors:  M S Klempner; M Cendron; D J Wyler
Journal:  J Infect Dis       Date:  1983-09       Impact factor: 5.226

5.  C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp.

Authors:  S D Wright; P A Reddy; M T Jong; B W Erickson
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

6.  The macrophage-attachment glycoprotein gp63 is the predominant C3-acceptor site on Leishmania mexicana promastigotes.

Authors:  D G Russell
Journal:  Eur J Biochem       Date:  1987-04-01

7.  The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytosis of Leishmania promastigotes.

Authors:  D M Mosser; P J Edelson
Journal:  J Immunol       Date:  1985-10       Impact factor: 5.422

8.  Evidence that Leishmania donovani utilizes a mannose receptor on human mononuclear phagocytes to establish intracellular parasitism.

Authors:  M E Wilson; R D Pearson
Journal:  J Immunol       Date:  1986-06-15       Impact factor: 5.422

9.  Molecular cloning of the major surface antigen of leishmania.

Authors:  L L Button; W R McMaster
Journal:  J Exp Med       Date:  1988-02-01       Impact factor: 14.307

10.  Macrophage type 3 complement receptors mediate serum-independent binding of Leishmania donovani. Detection of macrophage-derived complement on the parasite surface by immunoelectron microscopy.

Authors:  A O Wozencraft; G Sayers; J M Blackwell
Journal:  J Exp Med       Date:  1986-10-01       Impact factor: 14.307
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  6 in total

1.  Extrachromosomal genetic complementation of surface metalloproteinase (gp63)-deficient Leishmania increases their binding to macrophages.

Authors:  X Liu; K P Chang
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

2.  Characterization of Leishmania major antigen-liposomes that protect BALB/c mice against cutaneous leishmaniasis.

Authors:  L P Kahl; R Lelchuk; C A Scott; J Beesley
Journal:  Infect Immun       Date:  1990-10       Impact factor: 3.441

3.  Opsonin-independent phagocytosis of group B streptococci: role of complement receptor type three.

Authors:  J M Antal; J V Cunningham; K J Goodrum
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

4.  Cloning and characterization of a gene encoding an immunoglobulin-binding receptor on the cell surface of some members of the family Trypanosomatidae.

Authors:  Antonio Campos-Neto; Isabelle Suffia; Karen A Cavassani; Shyian Jen; Kay Greeson; Pamela Ovendale; João S Silva; Steven G Reed; Yasir A W Skeiky
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

5.  Comparison of receptors required for entry of Leishmania major amastigotes into macrophages.

Authors:  R A Guy; M Belosevic
Journal:  Infect Immun       Date:  1993-04       Impact factor: 3.441

6.  Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis.

Authors:  P E Kima; S L Constant; L Hannum; M Colmenares; K S Lee; A M Haberman; M J Shlomchik; D McMahon-Pratt
Journal:  J Exp Med       Date:  2000-03-20       Impact factor: 14.307
  6 in total

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