Xue Fan1,2, Li Zhang1,2, Jun Tang3,4, Chao Chen1,2, Juan Chen1,2, Yi Qu1,2, Dezhi Mu1,2. 1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. 2. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. 3. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. tj1234753@sina.com. 4. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. tj1234753@sina.com.
Abstract
OBJECTIVE: To investigate the correlation between the initial prophylactic antibiotic use and the subsequent NEC in high-risk premature infants. METHODS: We performed a literature search of PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Web of Science, and nine studies with a total of 5207 infants were selected for inclusion in this study. RESULTS: The pooled estimate for the seven studies combined indicating that prophylactic antibiotic usage was associated with a non-significant trend toward increased incidence of NEC [odds ratio (OR) 0.75; 95% confidence interval (CI) 0.26-2.17], and prolonged exposure to prophylactic antibiotics, compared with limited prophylactic antibiotic use, was associated with a significant trend toward the risk of increasing incidence of NEC (OR 1.31; 95% CI 1.08-1.59). CONCLUSION: Current evidence does not support the use of prophylactic antibiotics to reduce the incidence of NEC for high-risk premature infants.
OBJECTIVE: To investigate the correlation between the initial prophylactic antibiotic use and the subsequent NEC in high-risk premature infants. METHODS: We performed a literature search of PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Web of Science, and nine studies with a total of 5207 infants were selected for inclusion in this study. RESULTS: The pooled estimate for the seven studies combined indicating that prophylactic antibiotic usage was associated with a non-significant trend toward increased incidence of NEC [odds ratio (OR) 0.75; 95% confidence interval (CI) 0.26-2.17], and prolonged exposure to prophylactic antibiotics, compared with limited prophylactic antibiotic use, was associated with a significant trend toward the risk of increasing incidence of NEC (OR 1.31; 95% CI 1.08-1.59). CONCLUSION: Current evidence does not support the use of prophylactic antibiotics to reduce the incidence of NEC for high-risk premature infants.
Authors: Joseph Schulman; Robert J Dimand; Henry C Lee; Grace V Duenas; Mihoko V Bennett; Jeffrey B Gould Journal: Pediatrics Date: 2015-04-20 Impact factor: 7.124
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