Literature DB >> 29127205

Orchestrating phospholipid biosynthesis: Phosphatidic acid conducts and Opi1p performs.

Michael Salsaa1, Kendall Case1, Miriam L Greenberg2.   

Abstract

Phosphatidic acid (PA) and the conserved integral ER membrane protein Scs2p regulate localization of the transcriptional repressor Opi1p, which controls expression of phospholipid biosynthesis genes, but the mechanisms conducting Opi1p localization are not fully understood. A new study suggests the existence of a distinct pool of PA in the ER that is required for regulation of Opi1p localization and thus phospholipid metabolism in yeast.
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

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Year:  2017        PMID： 29127205      PMCID： PMC5682977          DOI： 10.1074/jbc.H117.809970

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

Review 1.  Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae.

Authors:  George M Carman; Gil-Soo Han
Journal:  Annu Rev Biochem       Date:  2011       Impact factor: 23.643

2.  Inositol synthesis regulates the activation of GSK-3α in neuronal cells.

Authors:  Cunqi Ye; Miriam L Greenberg
Journal:  J Neurochem       Date:  2014-11-17       Impact factor: 5.372

3.  Interaction between repressor Opi1p and ER membrane protein Scs2p facilitates transit of phosphatidic acid from the ER to mitochondria and is essential for INO1 gene expression in the presence of choline.

Authors:  Maria L Gaspar; Yu-Fang Chang; Stephen A Jesch; Manuel Aregullin; Susan A Henry
Journal:  J Biol Chem       Date:  2017-09-18       Impact factor: 5.157

4.  Phosphorylation of Dgk1 Diacylglycerol Kinase by Casein Kinase II Regulates Phosphatidic Acid Production in Saccharomyces cerevisiae.

Authors:  Yixuan Qiu; Azam Hassaninasab; Gil-Soo Han; George M Carman
Journal:  J Biol Chem       Date:  2016-11-10       Impact factor: 5.157

5.  Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells.

Authors:  Wenxi Yu; Cunqi Ye; Miriam L Greenberg
Journal:  J Biol Chem       Date:  2016-03-07       Impact factor: 5.157

6.  Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups.

Authors:  Petra Draskovic; Adolfo Saiardi; Rashna Bhandari; Adam Burton; Gregor Ilc; Miroslav Kovacevic; Solomon H Snyder; Marjetka Podobnik
Journal:  Chem Biol       Date:  2008-03

7.  cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase.

Authors:  Guimin Guan; Peihua Dai; Ishaiahu Shechter
Journal:  Arch Biochem Biophys       Date:  2003-09-15       Impact factor: 4.013

8.  Regulation of phosphatidylglycerophosphate synthase by inositol in Saccharomyces cerevisiae is not at the level of PGS1 mRNA abundance.

Authors:  Quan Zhong; Miriam L Greenberg
Journal:  J Biol Chem       Date:  2003-06-23       Impact factor: 5.157

9.  Deletion of the transcriptional regulator opi1p decreases cardiolipin content and disrupts mitochondrial metabolism in Saccharomyces cerevisiae.

Authors:  Luis Alberto Luévano-Martínez; Patricia Appolinario; Sayuri Miyamoto; Salvador Uribe-Carvajal; Alicia J Kowaltowski
Journal:  Fungal Genet Biol       Date:  2013-04-08       Impact factor: 3.495

10.  Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid.

Authors:  C J R Loewen; M L Gaspar; S A Jesch; C Delon; N T Ktistakis; S A Henry; T P Levine
Journal:  Science       Date:  2004-06-11       Impact factor: 47.728
  10 in total
  1 in total

1.  The glycerophosphocholine acyltransferase Gpc1 is part of a phosphatidylcholine (PC)-remodeling pathway that alters PC species in yeast.

Authors:  Sanket Anaokar; Ravindra Kodali; Benjamin Jonik; Mike F Renne; Jos F H M Brouwers; Ida Lager; Anton I P M de Kroon; Jana Patton-Vogt
Journal:  J Biol Chem       Date:  2018-12-04       Impact factor: 5.157
  1 in total

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