| Literature DB >> 29126955 |
Maryam Haghshomar1, Farzaneh Rahmani2, Mohammad Hadi Aarabi1, Shima Shahjouei3, Soheila Sobhani1, Maryam Rahmani4.
Abstract
Neuroinflammatory pathology has long been identified to contribute to the pathology of Parkinson disease. Early microstructural changes in white matter tracts might give a clue for earlier detection of PD. We investigated through diffusion MRI connectometry the structural correlates of white matter tracts of 81 patients with PD with whole blood neutrophil-to-lymphocyte ratio (NLR), controlling for age and sex. Diffusion data were reconstructed in the MNI space using q-space diffeomorphic reconstruction to obtain the spin distribution function. The spin distribution function (SDF) values were used in DMRI connectometry analysis. The connectometry analyses identified white matter QA of the following fibers to be correlated with NLR score after adjustment for age and sex: bilateral cingulum, body and left crus of fornix, bilateral corticospinal tract (CST), and body and splenium of corpus callosum (CC) and superior cerebellar peduncle with decreased connectivity related to NLR (FDR = 0.04542). Keeping with emerging evidence on the role of neuroinflammation in PD pathology, these results with functional relevance to prodromal Parkinson disease, bring new insights to pivotal role of peripheral inflammation in CNS neurodegeneration.Entities:
Keywords: Parkinson disease; connectometry; diffusion MRI; neutrophil-to-lymphocyte ratio (NLR)
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Year: 2017 PMID： 29126955 DOI： 10.1016/j.neuroscience.2017.10.050
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590