| Literature DB >> 29126731 |
Hassan M Faidallah1, Adel S Girgis2, Anand D Tiwari3, Hitesh H Honkanadavar4, Sean J Thomas4, Ahmed Samir5, Atef Kalmouch6, Khalid A Alamry1, Khalid A Khan1, Tarek S Ibrahim7, Amany M M Al-Mahmoudy8, Abdullah M Asiri1, Siva S Panda9.
Abstract
A set of 1,2,3-triazole incorporated quinolone antibiotic conjugates 10-15, 17-19 were synthesized via microwave assisted click chemistry technique. Some of the aryl-substituted conjugates 17-19 show promising antibacterial properties against the tested Gram-positive (S. aureus and S. pyogenes) and Gram-negative bacteria (S. typhi) with potency higher than that of the parent antibiotics 1-3. 2D-QSAR modeling supports the observed biological properties.Entities:
Keywords: 1,2,3-Triazole; Antibacterial; Conjugate; QSAR; Quinolone
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Year: 2017 PMID： 29126731 DOI： 10.1016/j.ejmech.2017.10.042
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514