Dong-Uk Park1, Seung-Hun Ryu2, Hyun-Suk Roh3, Eun Lee4, Hyun-Ju Cho5, Jisun Yoon6, So-Yeon Lee6, Young Ah Cho7, Kyung-Hyun Do7, Soo-Jong Hong8. 1. Department of Environmental Health, Korea National Open University, Seoul, Republic of Korea. 2. Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. 3. Tiny Labs, Incheon, Republic of Korea. 4. Department of Pediatrics, Chonnam National University Hospital, Gwangju, Republic of Korea. 5. Department of Pediatrics, Mediplex Sejong Hospital, Incheon, Republic of Korea. 6. Department of Pediatrics, Childhood Asthma and Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 7. Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 8. Department of Pediatrics, Childhood Asthma and Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: sjhong@amc.seoul.kr.
Abstract
BACKGROUND: Children aged ≤6years reportedly account for 52% of victims of humidifier disinfectant-associated lung injuries. OBJECTIVES: To evaluate the association of humidifier disinfectants with lung injury risk among children aged ≤6years. METHODS: Patients with humidifier disinfectant-associated lung injuries (n=214) who were clinically evaluated to have a definite (n=108), probable (n=49), or possible (n=57) association with humidifier disinfectants as well as control patients (n=123) with lung injury deemed unlikely to be associated with humidifier disinfectant use were evaluated to determine factors associated with increased risk of humidifier disinfectant-associated lung injury using unconditional multiple logistic regression analysis. RESULTS: For estimated airborne humidifier disinfectant concentrations, risk of humidifier disinfectant-associated lung injury increased ≥two-fold in a dose-dependent manner in the highest quartile (Q4, 135-1443μg/m3) compared with that in the lowest quartile (Q1, ≤33μg/m3). Registered patients using more than two humidifier disinfectant brands were at an increased risk of humidifier disinfectant-associated lung injury (adjusted OR, 2.2; 95% confidence interval, 1.3-3.8) compared with those using only one brand. With respect to the duration of humidifier disinfectant use, risk of humidifier disinfectant-associated lung injury increased ≥two-fold in the lowest quartile (≤5months) compared with that in the highest quartile (≥14months; adjusted OR 0.3; 95% confidence interval, 0.2-0.6). CONCLUSIONS: Younger children are more vulnerable to HDLI when exposed to HD chemicals within short period in early life.
BACKGROUND:Children aged ≤6years reportedly account for 52% of victims of humidifier disinfectant-associated lung injuries. OBJECTIVES: To evaluate the association of humidifier disinfectants with lung injury risk among children aged ≤6years. METHODS:Patients with humidifier disinfectant-associated lung injuries (n=214) who were clinically evaluated to have a definite (n=108), probable (n=49), or possible (n=57) association with humidifier disinfectants as well as control patients (n=123) with lung injury deemed unlikely to be associated with humidifier disinfectant use were evaluated to determine factors associated with increased risk of humidifier disinfectant-associated lung injury using unconditional multiple logistic regression analysis. RESULTS: For estimated airborne humidifier disinfectant concentrations, risk of humidifier disinfectant-associated lung injury increased ≥two-fold in a dose-dependent manner in the highest quartile (Q4, 135-1443μg/m3) compared with that in the lowest quartile (Q1, ≤33μg/m3). Registered patients using more than two humidifier disinfectant brands were at an increased risk of humidifier disinfectant-associated lung injury (adjusted OR, 2.2; 95% confidence interval, 1.3-3.8) compared with those using only one brand. With respect to the duration of humidifier disinfectant use, risk of humidifier disinfectant-associated lung injury increased ≥two-fold in the lowest quartile (≤5months) compared with that in the highest quartile (≥14months; adjusted OR 0.3; 95% confidence interval, 0.2-0.6). CONCLUSIONS: Younger children are more vulnerable to HDLI when exposed to HD chemicals within short period in early life.
Authors: Ji-Hun Song; Joonho Ahn; Min Young Park; Jaeyoung Park; Yu Min Lee; Jun-Pyo Myong; Jung-Wan Koo; Jongin Lee Journal: J Korean Med Sci Date: 2022-08-22 Impact factor: 5.354
Authors: Frank Li; Jiwoong Choi; Xuan Zhang; Prathish K Rajaraman; Chang-Hyun Lee; Hongseok Ko; Kum-Ju Chae; Eun-Kee Park; Alejandro P Comellas; Eric A Hoffman; Ching-Long Lin Journal: Int J Environ Res Public Health Date: 2022-09-20 Impact factor: 4.614