Masahiro Miyajima1, Atsushi Watanabe2, Toshihiko Sato3, Satoshi Teramukai4, Masahito Ebina5, Kazuma Kishi6, Yukihiko Sugiyama7, Haruhiko Kondo8, Satoru Kobayashi9, Yutaka Takahashi10, Hiroyuki Ito11, Ryoji Yamamoto12, Shigeki Sawada13, Hideki Fujimori14, Kazunori Okabe15, Jun Arikura16, Yasushi Shintani17, Hiroshige Nakamura18, Shinichi Toyooka19, Tohru Hasumi20, Takehiro Watanabe21, Yoshinobu Hata22, Hisashi Iwata23, Minoru Aoki24, Kazuhito Funai25, Shuhei Inoue26, Osamu Kawashima27, Tomohiko Iida28, Hiroshi Date3. 1. Department of Thoracic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan. miyajima@sapmed.ac.jp. 2. Department of Thoracic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan. 3. Department of Thoracic Surgery, Kyoto University, Kyoto, Japan. 4. Department of Biostatistics, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan. 5. Respiratory Center, Tohoku Pharmaceutical University Hospital, Sendai, Japan. 6. Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Tokyo, Japan. 7. Department of Pulmonary Medicine, Jichi Medical University, Tochigi, Japan. 8. Department of Thoracic Surgery, Kyorin University School of Medicine, Tokyo, Japan. 9. Department of General Thoracic Surgery, Dokkyo Medical University, Tochigi, Japan. 10. Department of Respiratory Surgery, Kobe City Medical Centre General Hospital, Kobe, Japan. 11. Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan. 12. Department of General Thoracic Surgery, Osaka City General Hospital, Osaka, Japan. 13. Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan. 14. Department of General Thoracic Surgery, Ishikawa Prefectural Central Hospital, Kanazawa, Japan. 15. Division of Thoracic Surgery, National Hospital Organization Yamaguchi-Ube Medical Center, Ube, Japan. 16. Department of Chest Surgery, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan. 17. Department of General Thoracic Surgery, Osaka University, Osaka, Japan. 18. Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Japan. 19. Department of Thoracic, Breast and Endocrinological Surgery, Okayama University, Okayama, Japan. 20. Department of Thoracic Surgery, Tohoku University Hospital, Sendai, Japan. 21. Department of Chest Surgery, National Hospital Organization Nishi-Niigata Chuo National Hospital, Nigata, Japan. 22. Department of Surgery, Toho University School of Medicine, Tokyo, Japan. 23. Department of General and Cardiothoracic Surgery, Graduate School of Medicine, Gifu University, Gifu, Japan. 24. Department of Thoracic Surgery, Nishi-Kobe Medical Center, Kobe, Japan. 25. First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan. 26. Department of General Thoracic Surgery, National Hospital Organization Higashi-Ohmi General Medical Center, Higashi-Ohmi, Japan. 27. Department of Thoracic Surgery, National Hospital Organization Nishigunma National Hospital, Gunma, Japan. 28. Department of General Thoracic Surgery, Kimitsu Central Hospital, Chiba, Japan.
Abstract
PURPOSES: Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. METHODS: We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3%) patients with a mortality rate of 43.9% (72/164). Univariate and multivariate analyses were carried out to identify possible risk factors of fatal AEIP. We then analyzed the 164 patients who developed postoperative AEIP and identified the preoperative and postoperative risk factors. RESULTS: A multivariate regression analysis identified that the sex, percent vital capacity, neoadjuvant radiation, preoperative history of AEIP, preoperative use of steroids, usual interstitial pneumonia pattern on CT, and surgical procedures were independent preoperative risk factors for death due to AEIP. ILD patients with emphysema somehow showed a lower risk of fatal AEIP than those without emphysema in this study. CONCLUSIONS: This study revealed eight risk factors for fatal AEIP.
PURPOSES: Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. METHODS: We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3%) patients with a mortality rate of 43.9% (72/164). Univariate and multivariate analyses were carried out to identify possible risk factors of fatal AEIP. We then analyzed the 164 patients who developed postoperative AEIP and identified the preoperative and postoperative risk factors. RESULTS: A multivariate regression analysis identified that the sex, percent vital capacity, neoadjuvant radiation, preoperative history of AEIP, preoperative use of steroids, usual interstitial pneumonia pattern on CT, and surgical procedures were independent preoperative risk factors for death due to AEIP. ILDpatients with emphysema somehow showed a lower risk of fatal AEIP than those without emphysema in this study. CONCLUSIONS: This study revealed eight risk factors for fatal AEIP.
Authors: H Taniguchi; M Ebina; Y Kondoh; T Ogura; A Azuma; M Suga; Y Taguchi; H Takahashi; K Nakata; A Sato; M Takeuchi; G Raghu; S Kudoh; T Nukiwa Journal: Eur Respir J Date: 2009-12-08 Impact factor: 16.671
Authors: Christopher J Ryerson; Thomas Hartman; Brett M Elicker; Brett Ley; Joyce S Lee; Marta Abbritti; Kirk D Jones; Talmadge E King; Jay Ryu; Harold R Collard Journal: Chest Date: 2013-07 Impact factor: 9.410
Authors: Namrata Kewalramani; Carlos Machahua; Venerino Poletti; Jacques Cadranel; Athol U Wells; Manuela Funke-Chambour Journal: ERJ Open Res Date: 2022-06-20