Georgia-Maria Kouli1, Demosthenes B Panagiotakos2,3, Ioannis Kyrou1,4,5,6, Emanuela Magriplis1, Ekavi N Georgousopoulou1,7, Christina Chrysohoou8, Constantine Tsigos1, Dimitrios Tousoulis8, Christos Pitsavos8. 1. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 176 71, Athens, Greece. 2. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 176 71, Athens, Greece. dbpanag@hua.gr. 3. Faculty of Health, University of Canberra, Canberra, Australia. dbpanag@hua.gr. 4. Aston Medical Research Institute, Aston Medical School, Aston University, B4 7ET, Birmingham, UK. 5. WISDEM, University Hospital Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK. 6. Translational and Experimental Medicine, Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK. 7. Faculty of Health, University of Canberra, Canberra, Australia. 8. First Cardiology Clinic, School of Medicine, University of Athens, 115 28, Athens, Greece.
Abstract
PURPOSE: Olive oil, being rich in mono-unsaturated fatty acids and anti-inflammatory compounds, may have protective effects against cardiovascular disease (CVD). The aim of the present work was to examine the association of olive oil consumption with the 10-year CVD incidence in adults without pre-existing CVD. METHODS: The ATTICA Study is a prospective, population-based study conducted in the greater metropolitan area of Athens (Attica, Greece). During 2001-2002, 3042 CVD-free adults (1514 men and 1528 women) were voluntarily recruited to the ATTICA study. Among various dietary habits, consumption of olive oil and other fats/oils was assessed at baseline; participants were classified into three groups (no use; mixed use; and exclusive use of olive oil). In 2011-2012, the 10-year study follow-up was performed, recording the fatal/non-fatal CVD incidence in 2020 participants (mean follow-up duration: 8.41 years). RESULTS: After controlling for various covariates, an inverse association between exclusive olive oil use and the risk of developing CVD was observed (relative risk 0.07, 95% CI: 0.01-0.66) compared to those not consuming olive oil. Further adjustment for fibrinogen plasma levels (among various inflammatory markers) showed a significant mediation effect on the previous association. CONCLUSIONS: These findings support exclusive olive oil consumption, a key component of the Mediterranean diet, for the primary CVD prevention, in adults without pre-existing disease. Circulating fibrinogen levels appear to play a mediating role in this relationship.
PURPOSE:Olive oil, being rich in mono-unsaturated fatty acids and anti-inflammatory compounds, may have protective effects against cardiovascular disease (CVD). The aim of the present work was to examine the association of olive oil consumption with the 10-year CVD incidence in adults without pre-existing CVD. METHODS: The ATTICA Study is a prospective, population-based study conducted in the greater metropolitan area of Athens (Attica, Greece). During 2001-2002, 3042 CVD-free adults (1514 men and 1528 women) were voluntarily recruited to the ATTICA study. Among various dietary habits, consumption of olive oil and other fats/oils was assessed at baseline; participants were classified into three groups (no use; mixed use; and exclusive use of olive oil). In 2011-2012, the 10-year study follow-up was performed, recording the fatal/non-fatal CVD incidence in 2020 participants (mean follow-up duration: 8.41 years). RESULTS: After controlling for various covariates, an inverse association between exclusive olive oil use and the risk of developing CVD was observed (relative risk 0.07, 95% CI: 0.01-0.66) compared to those not consuming olive oil. Further adjustment for fibrinogen plasma levels (among various inflammatory markers) showed a significant mediation effect on the previous association. CONCLUSIONS: These findings support exclusive olive oil consumption, a key component of the Mediterranean diet, for the primary CVD prevention, in adults without pre-existing disease. Circulating fibrinogen levels appear to play a mediating role in this relationship.
Authors: Alma Rus; Francisco Molina; María Josefa Martínez-Ramírez; María Encarnación Aguilar-Ferrándiz; Ramón Carmona; María Luisa Del Moral Journal: Nutrients Date: 2020-03-27 Impact factor: 5.717
Authors: Shafqat Ahmad; M Vinayaga Moorthy; Olga V Demler; Frank B Hu; Paul M Ridker; Daniel I Chasman; Samia Mora Journal: JAMA Netw Open Date: 2018-12-07