Literature DB >> 29124323

[Goodpasture syndrome: ocular manifestation in a young man].

C Lommatzsch1, A Lommatzsch2,3, C Heinz2,3, A Heiligenhaus2,3.   

Abstract

Goodpasture syndrome (GS) is a rare organ-specific autoimmune disease that may consist of glomerulonephritis and pulmonary hemorrhage. Only few case reports have been published on ocular symptoms in the context of GS. This is a case report of a 22-year-old male with GS who was referred to our practice because of visual disturbances. The anamnesis revealed pulmonary hemorrhage, acute renal failure and nephrotic syndrome, which was treated by immunosuppressive therapy with additional plasmapheresis. Ophthalmoscopically, bilateral cotton wool spots were found along the vessels and bilateral retinal hemorrhages predominantly at the posterior pole. By intensifying the existing antihypertensive therapy the eyesight showed significant improvement. Although infrequently seen in Goodpasture syndrome it is important to be aware of ocular symptoms as they may be the initial signs of GS.

Entities:  

Keywords:  Cotton wool spots; Eye manifestation; Glomerulonephritis; Goodpasture syndrome; Renal failure

Mesh:

Year:  2018        PMID: 29124323     DOI: 10.1007/s00347-017-0612-x

Source DB:  PubMed          Journal:  Ophthalmologe        ISSN: 0941-293X            Impact factor:   1.059


  13 in total

Review 1.  Goodpasture's disease: a report of ten cases and a review of the literature.

Authors:  Franco Dammacco; Stefano Battaglia; Loreto Gesualdo; Vito Racanelli
Journal:  Autoimmun Rev       Date:  2013-06-24       Impact factor: 9.754

2.  Landmark publication from The American Journal of the Medical Sciences: The significance of certain pulmonary lesions in relation to the etiology of influenza.

Authors:  Ernest W Goodpasture
Journal:  Am J Med Sci       Date:  2009-08       Impact factor: 2.378

3.  Bilateral serous retinal detachments associated with Goodpasture's syndrome.

Authors:  S Sharma
Journal:  Can J Ophthalmol       Date:  1998-06       Impact factor: 1.882

Review 4.  Diagnosis and classification of Goodpasture's disease (anti-GBM).

Authors:  Thomas Hellmark; Mårten Segelmark
Journal:  J Autoimmun       Date:  2014-01-21       Impact factor: 7.094

5.  Ocular clinical findings and basement membrane changes in Goodpasture's syndrome.

Authors:  L M Jampol; M Lahov; D M Albert; J Craft
Journal:  Am J Ophthalmol       Date:  1975-03       Impact factor: 5.258

6.  [Orbital tumor in Goodpasture's syndrome (author's transl)].

Authors:  W Hauff; P Till
Journal:  Klin Monbl Augenheilkd       Date:  1978-02       Impact factor: 0.700

Review 7.  Anti-glomerular basement membrane antibody disease: a rare autoimmune disorder affecting the kidney and the lung.

Authors:  Tobias Lahmer; Uwe Heemann
Journal:  Autoimmun Rev       Date:  2012-04-23       Impact factor: 9.754

8.  [Unusual course of Goodpasture syndrome].

Authors:  U Köhler
Journal:  Klin Monbl Augenheilkd       Date:  1988-04       Impact factor: 0.700

9.  Rapidly progressive glomerulonephritis. Combined antiglomerular basement membrane antibody and immune complex pathogenesis.

Authors:  A V Richman; S I Rifkin; C J McAllister
Journal:  Hum Pathol       Date:  1981-07       Impact factor: 3.466

10.  Ophthalmic features of fourteen cases of Goodpasture's syndrome.

Authors:  P A Rowe; D C Mansfield; G N Dutton
Journal:  Nephron       Date:  1994       Impact factor: 2.847

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