Alberto Pérez-Castellanos1, Manuel Martínez-Sellés2, Hernán Mejía-Rentería3, Mireia Andrés4, Alessandro Sionis5, Manuel Almendro-Delia6, Ana Martín-García7, María Cruz Aguilera8, Eduardo Pereyra9, José A Linares Vicente10, Bernardo García de la Villa1, Iván J Núñez-Gil11. 1. Servicio de Cardiología, Hospital de Manacor, Manacor, Balearic Islands, Spain. 2. Servicio de Cardiología, Hospital General Universitario Gregorio Marañón, CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; Universidad Complutense y Universidad Europea, Madrid, Spain. 3. Servicio de Cardiología, Instituto Cardiovascular, Hospital Clínico San Carlos, Madrid, Spain. 4. Servicio de Cardiología, Hospital Universitario Vall d'Hebron, Barcelona, Spain. 5. Unidad de Cuidados Intensivos Cardiológicos, Servicio de Cardiología, Hospital de Sant Pau, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain. 6. Servicio de Cardiología, Hospital Virgen de la Macarena, Sevilla, Spain. 7. Servicio de Cardiología, Hospital Universitario de Salamanca, Instituto de Investigacion Biomédica de Salamanca (IBSAL), CIBER de Enfermedades Cardiovasculares (CIBERCV), Salamanca, Spain. 8. Servicio de Cardiología, Hospital de La Princesa, Madrid, Spain. 9. Servicio de Cardiología, Hospital Universitario Arnau de Vilanova, Lérida, Spain. 10. Servicio de Cardiología, Hospital Clínico Lozano Blesa, Zaragoza, Spain. 11. Servicio de Cardiología, Instituto Cardiovascular, Hospital Clínico San Carlos, Madrid, Spain. Electronic address: ibnsky@yahoo.es.
Abstract
INTRODUCTION AND OBJECTIVES: Tako-tsubo syndrome is a potentially serious disease during the acute phase. It mimics myocardial infarction, but with no potentially causative coronary lesions. The aim of this study was to analyze the clinical course and outcome of patients with tako-tsubo syndrome by sex. METHODS: We analyzed the characteristics of patients included in the RETAKO registry from 2003 to 2015, a multicenter registry with participation of 32 Spanish hospitals. RESULTS: Of 562 patients included, 493 (87.7%) were women. Chest pain was less frequent as an initial symptom in men than in women (43 [66.2%] vs 390 [82.8%]; P < .01). The prognosis was worse in men, with higher in-hospital mortality (3 [4.4%] vs 1 [0.2%]; P < .01), longer intensive care stay (4.2 ± 3.7 vs 3.2 ± 3.2 days; P = .03) and a higher frequency of severe heart failure (22 [33.3%] vs 95 [20.3%]; P = .02). However, dynamic obstruction at the left-ventricular outflow tract occurred exclusively in women (39 [7.9%] vs 0 [0.0%]; P = .02). The incidence of functional mitral regurgitation was also higher in women (52 [10.6%] vs 2 [2.9%]; P = .04). CONCLUSIONS: Tako-tsubo syndrome shows wide differences by sex in terms of its incidence, presentation, and outcomes. Prognosis is worse in men.
INTRODUCTION AND OBJECTIVES:Tako-tsubo syndrome is a potentially serious disease during the acute phase. It mimics myocardial infarction, but with no potentially causative coronary lesions. The aim of this study was to analyze the clinical course and outcome of patients with tako-tsubo syndrome by sex. METHODS: We analyzed the characteristics of patients included in the RETAKO registry from 2003 to 2015, a multicenter registry with participation of 32 Spanish hospitals. RESULTS: Of 562 patients included, 493 (87.7%) were women. Chest pain was less frequent as an initial symptom in men than in women (43 [66.2%] vs 390 [82.8%]; P < .01). The prognosis was worse in men, with higher in-hospital mortality (3 [4.4%] vs 1 [0.2%]; P < .01), longer intensive care stay (4.2 ± 3.7 vs 3.2 ± 3.2 days; P = .03) and a higher frequency of severe heart failure (22 [33.3%] vs 95 [20.3%]; P = .02). However, dynamic obstruction at the left-ventricular outflow tract occurred exclusively in women (39 [7.9%] vs 0 [0.0%]; P = .02). The incidence of functional mitral regurgitation was also higher in women (52 [10.6%] vs 2 [2.9%]; P = .04). CONCLUSIONS:Tako-tsubo syndrome shows wide differences by sex in terms of its incidence, presentation, and outcomes. Prognosis is worse in men.
Keywords:
Gender; Insuficiencia mitral; Left ventricular outflow tract obstruction; Mitral regurgitation; Obstrucción en tracto de salida del ventrículo izquierdo; Sexo; Síndrome de tako-tsubo; Tako-tsubo syndrome
Authors: Ekaterina S Prokudina; Boris K Kurbatov; Konstantin V Zavadovsky; Alexander V Vrublevsky; Natalia V Naryzhnaya; Yuri B Lishmanov; Leonid N Maslov; Peter R Oeltgen Journal: Curr Cardiol Rev Date: 2021