Literature DB >> 29122440

Exploiting the human peptidome for novel antimicrobial and anticancer agents.

Matteo Bosso1, Ludger Ständker2, Frank Kirchhoff3, Jan Münch4.   

Abstract

Infectious diseases and cancers are leading causes of death and pose major challenges to public health. The human peptidome encompasses millions of compounds that display an enormous structural and functional diversity and represents an excellent source for the discovery of endogenous agents with antimicrobial and/or anticancer activity. Here, we discuss how to exploit the human peptidome for novel antimicrobial and anticancer agents through the generation of peptide libraries from human body fluids and tissues and stepwise purification of bioactive compounds.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anticancer peptide; Antimicrobial peptide; Peptide libraries; Peptidome

Mesh：

Substances：

Year:  2017        PMID： 29122440     DOI： 10.1016/j.bmc.2017.10.038

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

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Authors:  Sevil Şenkardeş; Necla Kulabaş; Özlem Bingöl Özakpinar; Sadık Kalayci; Fikrettin Şahin; İlkay Küçükgüzel; Ş Güniz Küçükgüzel
Journal:  Turk J Pharm Sci       Date:  2020-02-19

2.  A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity.

Authors:  Rüdiger Groß; Richard Bauer; Franziska Krüger; Elke Rücker-Braun; Lia-Raluca Olari; Ludger Ständker; Nico Preising; Armando A Rodríguez; Carina Conzelmann; Fabian Gerbl; Daniel Sauter; Frank Kirchhoff; Benjamin Hagemann; Jasmina Gačanin; Tanja Weil; Yasser B Ruiz-Blanco; Elsa Sanchez-Garcia; Wolf-Georg Forssmann; Annette Mankertz; Sabine Santibanez; Steffen Stenger; Paul Walther; Sebastian Wiese; Barbara Spellerberg; Jan Münch
Journal:  Front Microbiol       Date:  2020-04-06       Impact factor: 5.640

Review 3.  Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response.

Authors:  Derry K Mercer; Deborah A O'Neil
Journal:  Front Immunol       Date:  2020-09-17       Impact factor: 7.561

Review 4.  Emerging Computational Approaches for Antimicrobial Peptide Discovery.

Authors:  Guillermin Agüero-Chapin; Deborah Galpert-Cañizares; Dany Domínguez-Pérez; Yovani Marrero-Ponce; Gisselle Pérez-Machado; Marta Teijeira; Agostinho Antunes
Journal:  Antibiotics (Basel)       Date:  2022-07-13

Review 5.  Antimicrobial Peptides with Anti-Candida Activity.

Authors:  Aitzol Perez-Rodriguez; Elena Eraso; Guillermo Quindós; Estibaliz Mateo
Journal:  Int J Mol Sci       Date:  2022-08-17       Impact factor: 6.208

6.  Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract of Annona muricata.

Authors:  Wisdom O Iyanda-Joel; Olusayo B Ajetunmobi; Shalom N Chinedu; Emeka E J Iweala; Oluwatobi S Adegbite
Journal:  J Toxicol       Date:  2019-12-31

Review 7.  Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery.

Authors:  Marcin Makowski; Ítala C Silva; Constança Pais do Amaral; Sónia Gonçalves; Nuno C Santos
Journal:  Pharmaceutics       Date:  2019-11-08       Impact factor: 6.321

8.  Respiratory ß-2-Microglobulin exerts pH dependent antimicrobial activity.

Authors:  Armin Holch; Richard Bauer; Lia-Raluca Olari; Armando A Rodriguez; Ludger Ständker; Nico Preising; Merve Karacan; Sebastian Wiese; Paul Walther; Yasser B Ruiz-Blanco; Elsa Sanchez-Garcia; Christian Schumann; Jan Münch; Barbara Spellerberg
Journal:  Virulence       Date:  2020-12       Impact factor: 5.882
  8 in total

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