Yan Liu1, Rong-Shao Tan2, Dao-Yuan Zhou3, Xiao Xiao4, Jian-Min Ran3, Dan-Ping Qin4, Xiao-Shi Zhong4, Jian-Guang Hu4, Yun Liu3, Yuan-Yuan Zheng4. 1. Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China; Guangzhou Institute of Disease-Oriented Nutritional Research, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China. Electronic address: rabbityan127@163.com. 2. Guangzhou Institute of Disease-Oriented Nutritional Research, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China. 3. Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China; Guangzhou Institute of Disease-Oriented Nutritional Research, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China. 4. Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China.
Abstract
BACKGROUND: Chronic kidney disease (CKD) is a serious condition associated with early mortality, decreased quality of life, and increased health-care expenditures. METHODS: Data from the National Health and Nutrition Examination Survey (NHANES) collected from 1999 to 2012 were used. Subjects were divided into 4 estimated glomerular filtration rate (eGFR) categories: stage 1: eGFR≥90mL/min/1.73m2, stage 2: eGFR 60-89, stage 3: eGFR 30-59, and stage 4/5: eGFR<30, and 3 age strata (<45y, 45-64, 65+). Associations between protein intake and albuminuria were determined. RESULTS: A total of 45,259 subjects were included. Despite decreasing protein intake, there was a significant increase in the prevalence of albuminuria with decreasing levels of eGFR. Multivariable analysis showed that albuminuria was associated with daily protein intake in patients ≥65years old with stage 1 disease, and that diabetes was associated with albuminuria in patients ≥65years old with stage 2 and 3 diseases. Overall, albuminuria in patients with stage 1 disease was associated with hours of sitting per day and blood glucose level. CONCLUSION: Albuminuria was associated with daily protein intake in patients of 45-64years old with stage 1 CKD disease, and was associated with hours of sitting per day and blood glucose level. These data further support the importance of lifestyle changes in the management of CKD, especially in patients with early-stage disease.
BACKGROUND:Chronic kidney disease (CKD) is a serious condition associated with early mortality, decreased quality of life, and increased health-care expenditures. METHODS: Data from the National Health and Nutrition Examination Survey (NHANES) collected from 1999 to 2012 were used. Subjects were divided into 4 estimated glomerular filtration rate (eGFR) categories: stage 1: eGFR≥90mL/min/1.73m2, stage 2: eGFR 60-89, stage 3: eGFR 30-59, and stage 4/5: eGFR<30, and 3 age strata (<45y, 45-64, 65+). Associations between protein intake and albuminuria were determined. RESULTS: A total of 45,259 subjects were included. Despite decreasing protein intake, there was a significant increase in the prevalence of albuminuria with decreasing levels of eGFR. Multivariable analysis showed that albuminuria was associated with daily protein intake in patients ≥65years old with stage 1 disease, and that diabetes was associated with albuminuria in patients ≥65years old with stage 2 and 3 diseases. Overall, albuminuria in patients with stage 1 disease was associated with hours of sitting per day and blood glucose level. CONCLUSION:Albuminuria was associated with daily protein intake in patients of 45-64years old with stage 1 CKD disease, and was associated with hours of sitting per day and blood glucose level. These data further support the importance of lifestyle changes in the management of CKD, especially in patients with early-stage disease.
Authors: Sarah J Schrauben; Apurva Inamdar; Christina Yule; Sara Kwiecien; Caitlin Krekel; Charlotte Collins; Cheryl Anderson; Lisa Bailey-Davis; Alex R Chang Journal: J Ren Nutr Date: 2021-10-11 Impact factor: 3.655