Yu Liao1, Lin Xu1, Xiao Lin1, Yuan Tao Hao2. 1. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China. 2. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China; Sun Yat-sen Global Health Institute, Institute of State Governance, Sun Yat-sen University, Guangzhou 510275, Guangdong, China.
Abstract
OBJECTIVE: To estimate the lung cancer burden that may be attributable to ambient fine particulate matter (PM2.5) pollution in Guangzhou city in China from 2005 to 2013. METHODS: The data regarding PM2.5 exposure were obtained from the 'Ambient air pollution exposure estimation for the Global Burden of Disease 2013' dataset at 0.1° ×0.1° spatial resolution. Disability-adjusted life years (DALYs) were estimated based on the information of mortality and incidence of lung cancer. Comparative risk analysis and integrated exposure-response function were used to estimate attributed disease burden. RESULTS: The population-weighted average concentration of PM2.5 was increased by 34.6% between 1990 and 2013, from 38.37 μg/m3 to 51.31 μg/m3. The lung cancer DALYs in both men and women were increased by 36.2% from 2005 to 2013. The PM2.5 attributed lung cancer DALYs increased from 12105.0 (8181.0 for males and 3924.0 for females) in 2005 to 16489.3 (11291.7 for males and 5197.6 for females) in 2013. An average of 23.1% lung cancer burden was attributable to PM2.5 pollution in 2013. CONCLUSION: PM2.5 has caused serious but under-appreciated public health burden in Guangzhou and the trend deteriorates. Effective strategies are needed to tackle this major public health problem.
OBJECTIVE: To estimate the lung cancer burden that may be attributable to ambient fine particulate matter (PM2.5) pollution in Guangzhou city in China from 2005 to 2013. METHODS: The data regarding PM2.5 exposure were obtained from the 'Ambient air pollution exposure estimation for the Global Burden of Disease 2013' dataset at 0.1° ×0.1° spatial resolution. Disability-adjusted life years (DALYs) were estimated based on the information of mortality and incidence of lung cancer. Comparative risk analysis and integrated exposure-response function were used to estimate attributed disease burden. RESULTS: The population-weighted average concentration of PM2.5 was increased by 34.6% between 1990 and 2013, from 38.37 μg/m3 to 51.31 μg/m3. The lung cancer DALYs in both men and women were increased by 36.2% from 2005 to 2013. The PM2.5 attributed lung cancer DALYs increased from 12105.0 (8181.0 for males and 3924.0 for females) in 2005 to 16489.3 (11291.7 for males and 5197.6 for females) in 2013. An average of 23.1% lung cancer burden was attributable to PM2.5 pollution in 2013. CONCLUSION: PM2.5 has caused serious but under-appreciated public health burden in Guangzhou and the trend deteriorates. Effective strategies are needed to tackle this major public health problem.
Authors: Rayjean J Hung; Margaret R Spitz; Richard S Houlston; Ann G Schwartz; John K Field; Jun Ying; Yafang Li; Younghun Han; Xuemei Ji; Wei Chen; Xifeng Wu; Ivan P Gorlov; Jie Na; Mariza de Andrade; Geoffrey Liu; Yonathan Brhane; Nancy Diao; Angela Wenzlaff; Michael P A Davies; Triantafillos Liloglou; Maria Timofeeva; Thomas Muley; Hedy Rennert; Walid Saliba; Bríd M Ryan; Elise Bowman; Juan-Miguel Barros-Dios; Mónica Pérez-Ríos; Hal Morgenstern; Shanbeh Zienolddiny; Vidar Skaug; Donatella Ugolini; Stefano Bonassi; Erik H F M van der Heijden; Adonina Tardon; Stig E Bojesen; Maria Teresa Landi; Mattias Johansson; Heike Bickeböller; Susanne Arnold; Loic Le Marchand; Olle Melander; Angeline Andrew; Kjell Grankvist; Neil Caporaso; M Dawn Teare; Matthew B Schabath; Melinda C Aldrich; Lambertus A Kiemeney; H-Erich Wichmann; Philip Lazarus; Jose Mayordomo; Monica Neri; Aage Haugen; Zuo-Feng Zhang; Alberto Ruano-Raviña; Hermann Brenner; Curtis C Harris; Irene Orlow; Gadi Rennert; Angela Risch; Paul Brennan; David C Christiani; Christopher I Amos; Ping Yang; Olga Y Gorlova Journal: J Thorac Oncol Date: 2019-04-19 Impact factor: 15.609