Tobias Gauss1, Sébastien Campion, Sébastien Kerever, Mathilde Eurin, Mathieu Raux, Anatole Harrois, Catherine Paugam-Burtz, Sophie Hamada. 1. From the Hôpital Beaujon, Assistance Publique Hôpitaux de Paris, Hôpitaux Universitaires Paris Nord Val de Seine, Clichy(TG, SC, ME, CP-B), Service d'Anesthésie- Réanimation, Hôpital Lariboisière, Assistance Publique Hôpitaux de Paris (SK), Université Denis Diderot - Paris VII (SK, CP-B), Département d'Anesthésie Réanimation, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Assistance Publique Hôpitaux de Paris(MR), Sorbonne Universités, UPMC Université Paris 06, UMRS INSERM 1158, Paris (SC, MR) and Service d'Anesthésie-Réanimation, Hôpital Bicêtre, Groupement Hôpitaux Universitaires Paris Sud, Assistance Publique Hôpitaux de Paris, Le Kremlin Bicêtre, France (AH, SH).
Abstract
BACKGROUND: Early recognition of low fibrinogen concentrations in trauma patients is crucial for timely haemostatic treatment and laboratory testing is too slow to inform decision-making. OBJECTIVE: To develop a simple clinical tool to predict low fibrinogen concentrations in trauma patients on arrival. DESIGN: Retrospective cohort study. SETTING: Three designated level 1 trauma centres in the Paris Region, from January 2011 to December 2013. PATIENTS: Patients admitted in accordance with national triage guidelines for major trauma and plasma fibrinogen concentration testing on admission. INTERVENTION: Construction of a clinical score [Fibrinogen on Admission in Trauma (FibAT) score] in a derivation cohort to predict fibrinogen plasma concentration 1.5 g l or less after multiple regressions. One point was given for each predictive factor. The score was the sum of all. Validation was performed in a separate validation cohort. MAIN OUTCOME MEASURE: Predictive accuracy of FibAT score. RESULTS: In total, 2936 patients were included, 2124 in the derivation cohort and 812 in the validation cohort. In the derivation cohort, a multivariate logistic model identified the following predictive factors for plasma fibrinogen concentrations 1.5 g l or less: age less than 33 years, prehospital heart rate more than 100 beats per minute, prehospital SBP less than 100 mmHg, blood lactate concentration on admission more than 2.5 mmol l, free intraabdominal fluid on sonography, decrease in haemoglobin concentration from prehospital to admission of more than 2 g dl, capillary haemoglobin concentration on admission less than 12 g dl and temperature on admission less than 36°C. The FibAT score had an area under the receiver operating characteristic curve of 0.87 [95% confidence interval (0.86 to 0.91)] in the derivation cohort and of 0.82 (95% confidence interval (0.86 to 0.91)] in the validation cohort to predict a low plasma fibrinogen. CONCLUSION: The FibAT score accurately predicts plasma fibrinogen levels 1.5 g l or less on admission in trauma patients. This easy-to-use score could allow early, goal-directed therapy to trauma patients.
BACKGROUND: Early recognition of low fibrinogen concentrations in traumapatients is crucial for timely haemostatic treatment and laboratory testing is too slow to inform decision-making. OBJECTIVE: To develop a simple clinical tool to predict low fibrinogen concentrations in traumapatients on arrival. DESIGN: Retrospective cohort study. SETTING: Three designated level 1 trauma centres in the Paris Region, from January 2011 to December 2013. PATIENTS: Patients admitted in accordance with national triage guidelines for major trauma and plasma fibrinogen concentration testing on admission. INTERVENTION: Construction of a clinical score [Fibrinogen on Admission in Trauma (FibAT) score] in a derivation cohort to predict fibrinogen plasma concentration 1.5 g l or less after multiple regressions. One point was given for each predictive factor. The score was the sum of all. Validation was performed in a separate validation cohort. MAIN OUTCOME MEASURE: Predictive accuracy of FibAT score. RESULTS: In total, 2936 patients were included, 2124 in the derivation cohort and 812 in the validation cohort. In the derivation cohort, a multivariate logistic model identified the following predictive factors for plasma fibrinogen concentrations 1.5 g l or less: age less than 33 years, prehospital heart rate more than 100 beats per minute, prehospital SBP less than 100 mmHg, blood lactate concentration on admission more than 2.5 mmol l, free intraabdominal fluid on sonography, decrease in haemoglobin concentration from prehospital to admission of more than 2 g dl, capillary haemoglobin concentration on admission less than 12 g dl and temperature on admission less than 36°C. The FibAT score had an area under the receiver operating characteristic curve of 0.87 [95% confidence interval (0.86 to 0.91)] in the derivation cohort and of 0.82 (95% confidence interval (0.86 to 0.91)] in the validation cohort to predict a low plasma fibrinogen. CONCLUSION: The FibAT score accurately predicts plasma fibrinogen levels 1.5 g l or less on admission in traumapatients. This easy-to-use score could allow early, goal-directed therapy to traumapatients.
Authors: Pierre Bouzat; François-Xavier Ageron; Jonathan Charbit; Xavier Bobbia; Pauline Deras; Jennifer Bas Dit Nugues; Etienne Escudier; Guillaume Marcotte; Marc Leone; Jean-Stéphane David Journal: Scand J Trauma Resusc Emerg Med Date: 2018-07-09 Impact factor: 2.953
Authors: Florian Roquet; Arthur Neuschwander; Sophie Hamada; Gersende Favé; Arnaud Follin; David Marrache; Bernard Cholley; Romain Pirracchio Journal: JAMA Netw Open Date: 2019-09-04