Literature DB >> 29120750

Lysophosphatidate Signaling: The Tumor Microenvironment's New Nemesis.

Matthew G K Benesch1, Zelei Yang2, Xiaoyun Tang2, Guanmin Meng2, David N Brindley3.   

Abstract

Lysophosphatidate (LPA) is emerging as a potent mediator of cancer progression in the tumor microenvironment. Strategies for targeting LPA signaling have recently entered clinical trials for fibrosis. These therapies have potential to improve the efficacies of existing chemotherapies and radiotherapy by attenuating chronic inflammation, irrespective of diverse mutations within cancer cells.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  autotaxin; chemoresistance; lipid phosphate phosphatases; lysophosphatidic acid; metastasis; radiotherapy

Mesh：

Substances：

Year:  2017        PMID： 29120750     DOI： 10.1016/j.trecan.2017.09.004

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  18 in total

Review 1.  Role of autotaxin in cancer stem cells.

Authors:  Dongjun Lee; Dong-Soo Suh; Sue Chin Lee; Gabor J Tigyi; Jae Ho Kim
Journal:  Cancer Metastasis Rev       Date:  2018-09       Impact factor: 9.264

Review 2.  Platelets, autotaxin and lysophosphatidic acid signalling: win-win factors for cancer metastasis.

Authors:  Raphael Leblanc; Audrey Houssin; Olivier Peyruchaud
Journal:  Br J Pharmacol       Date:  2018-06-25       Impact factor: 8.739

3.  Lysophospholipids in Lung Inflammatory Diseases.

Authors:  Jing Zhao; Yutong Zhao
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 4.  Autotaxin in Pathophysiology and Pulmonary Fibrosis.

Authors:  Ioanna Ninou; Christiana Magkrioti; Vassilis Aidinis
Journal:  Front Med (Lausanne)       Date:  2018-06-13

Review 5.  Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer.

Authors:  David N Brindley; Xiaoyun Tang; Guanmin Meng; Matthew G K Benesch
Journal:  Int J Mol Sci       Date:  2020-08-18       Impact factor: 5.923

Review 6.  Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment.

Authors:  Yan Xu
Journal:  Cancers (Basel)       Date:  2018-07-09       Impact factor: 6.639

Review 7.  Models for measuring metabolic chemical changes in the metastasis of high grade serous ovarian cancer: fallopian tube, ovary, and omentum.

Authors:  Hannah Lusk; Joanna E Burdette; Laura M Sanchez
Journal:  Mol Omics       Date:  2021-12-06

Review 8.  Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation.

Authors:  Matthew G K Benesch; Iain T K MacIntyre; Todd P W McMullen; David N Brindley
Journal:  Cancers (Basel)       Date:  2018-03-15       Impact factor: 6.639

Review 9.  Autotaxin Implication in Cancer Metastasis and Autoimunne Disorders: Functional Implication of Binding Autotaxin to the Cell Surface.

Authors:  Olivier Peyruchaud; Lou Saier; Raphaël Leblanc
Journal:  Cancers (Basel)       Date:  2019-12-31       Impact factor: 6.639

10.  Transcriptomic and computational analysis identified LPA metabolism, KLHL14 and KCNE3 as novel regulators of Epithelial-Mesenchymal Transition.

Authors:  V Di Lollo; A Canciello; M Orsini; N Bernabò; M Ancora; M Di Federico; V Curini; M Mattioli; V Russo; A Mauro; C Cammà; B Barboni
Journal:  Sci Rep       Date:  2020-03-06       Impact factor: 4.379
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