Literature DB >> 29119833

Treatment of advanced basal cell carcinoma with sonidegib: perspective from the 30-month update of the BOLT trial.

Leon Chen1, Alexander B Aria2, Sirunya Silapunt1, Heng-Huan Lee3, Michael R Migden4.   

Abstract

Sonidegib, a hedgehog pathway inhibitor, was approved by the US FDA for the treatment of locally advanced basal cell carcinoma which cannot be readily treated with surgery or radiotherapy. The pharmacology and pharmacokinetics of sonidegib will be discussed in this review. Additionally, an in-depth analysis of the BOLT trial and data from the 30-month update will be included. This will serve as an update to a previously published article which reported the 12-month update of the BOLT trial.

Entities:  

Keywords:  BOLT; HPI; basal cell carcinoma; hedgehog pathway inhibitor; laBCC; locally advanced basal cell carcinoma; mBCC; metastatic basal cell carcinoma; sonidegib

Mesh：

Substances：

Year:  2017        PMID： 29119833     DOI： 10.2217/fon-2017-0457

Source DB:  PubMed          Journal:  Future Oncol        ISSN： 1479-6694            Impact factor:   3.404


  6 in total

1.  Efficiency of long-term high-dose intravenous ascorbic acid therapy in locally advanced basal cell carcinoma - a pilot study.

Authors:  András Bánvölgyi; Kende Lőrincz; Norbert Kiss; Pinar Avci; Luca Fésűs; Róbert Szipőcs; Tibor Krenács; Nóra Gyöngyösi; Norbert Wikonkál; Sarolta Kárpáti; Krisztián Németh
Journal:  Postepy Dermatol Alergol       Date:  2019-02-26       Impact factor: 1.837

2.  The use of hedgehog antagonists in cancer therapy: a comparison of clinical outcomes and gene expression analyses.

Authors:  Burthia E Booker; Adam D Steg; Stefan Kovac; Charles N Landen; Hope M Amm
Journal:  Cancer Biol Ther       Date:  2020-09-11       Impact factor: 4.742

3.  Invasive Basal Cell Carcinoma of the Skin Treated Successfully with Vismodegib: A Case Report.

Authors:  Ramez Awad; Juan Camilo Barreto Andrade; Heba Mousa; Fade Mahmoud
Journal:  Perm J       Date:  2018

Review 4.  Molecular Mechanisms and Targeted Therapies of Advanced Basal Cell Carcinoma.

Authors:  Toshihiko Hoashi; Naoko Kanda; Hidehisa Saeki
Journal:  Int J Mol Sci       Date:  2022-10-08       Impact factor: 6.208

Review 5.  Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma.

Authors:  Alessia Villani; Gabriella Fabbrocini; Claudia Costa; Massimiliano Scalvenzi
Journal:  Dermatol Ther (Heidelb)       Date:  2020-04-15

Review 6.  Basal Cell Carcinoma: A Comprehensive Review.

Authors:  Emi Dika; Federica Scarfì; Manuela Ferracin; Elisabetta Broseghini; Emanuela Marcelli; Barbara Bortolani; Elena Campione; Mattia Riefolo; Costantino Ricci; Martina Lambertini
Journal:  Int J Mol Sci       Date:  2020-08-04       Impact factor: 5.923
  6 in total

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