| Literature DB >> 29119513 |
Luca Casadei1, Mariacristina Valerio2, Cesare Manetti3.
Abstract
Metabolomics has the capability of providing predisposition, diagnostic, prognostic, and therapeutic biomarker profiles of individual patients, since a large number of metabolites can be measured in an unbiased manner from biological samples. In this setting, 1H-Nuclear Magnetic Resonance (NMR) spectroscopy of biofluids such as plasma, urine, and fecal water offers the opportunity to identify patterns of biomarker changes that reflects the physiological or pathological status of an individual patient.In this chapter, we show as a metabolomics study can be used to diagnose a disease, classifying patients as healthy or as pathological taking into account individual variability.Entities:
Keywords: Covariance analysis; Linear discriminant analysis; Metabolomics; NMR spectroscopy; Precision medicine; Principal component analysis
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Year: 2018 PMID： 29119513 DOI： 10.1007/978-1-4939-7456-6_16
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745