Keita Sakamoto1,2, Noriko Oyama-Manabe3, Osamu Manabe4, Tadao Aikawa5, Yasuka Kikuchi1,6, Harue Sasai-Masuko5, Masanao Naya5, Kohsuke Kudo1, Fumi Kato1, Nagara Tamaki7, Hiroki Shirato2. 1. Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Kita1 4, Nishi 5, Kita-ku, Sapporo, 060-8638, Japan. 2. Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 3. Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Kita1 4, Nishi 5, Kita-ku, Sapporo, 060-8638, Japan. norikooyama@med.hokudai.ac.jp. 4. Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 5. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 6. Center for Cause of Death Investigation, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 7. Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Abstract
PURPOSE: To evaluate heterogeneity of myocardial contraction in relation to extensive late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients with preserved left ventricular ejection fraction, using fast strain-encoded magnetic resonance imaging. MATERIALS AND METHODS: Twenty-two HCM patients and 24 age-matched control subjects were included in this retrospective study. The regional and global peak values of longitudinal and circumferential strain (LSregional, LSglobal, CSregional, CSglobal), and their regional heterogeneities were evaluated using coefficients of variation (LSCoV, CSCoV) in relation to LGE. Receiver operating characteristic curve analysis was performed to identify patients with a total left ventricular myocardial LGE ≥ 15%. RESULTS: LSglobal in HCM patients was significantly decreased compared to that in controls (- 14.4 ± 2.4% vs - 17.2 ± 2.0%; p = 0.0004), while CSglobal was not (p = 1.0). Negative LGE segments demonstrated decreased LSregional in HCM patients compared to in controls (p < 0.0001), while CSregional was not decreased. CSCoV demonstrated the largest area under the curve (AUC) (0.91), with high sensitivity (83%) and specificity (94%) for detection of HCM patients with extensive LGE, while the AUC of LSCoV was low (0.49). CONCLUSION: The heterogeneity in CSregional has a high diagnostic value for detection of HCM patients with extensive LGE.
PURPOSE: To evaluate heterogeneity of myocardial contraction in relation to extensive late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients with preserved left ventricular ejection fraction, using fast strain-encoded magnetic resonance imaging. MATERIALS AND METHODS: Twenty-two HCM patients and 24 age-matched control subjects were included in this retrospective study. The regional and global peak values of longitudinal and circumferential strain (LSregional, LSglobal, CSregional, CSglobal), and their regional heterogeneities were evaluated using coefficients of variation (LSCoV, CSCoV) in relation to LGE. Receiver operating characteristic curve analysis was performed to identify patients with a total left ventricular myocardial LGE ≥ 15%. RESULTS: LSglobal in HCM patients was significantly decreased compared to that in controls (- 14.4 ± 2.4% vs - 17.2 ± 2.0%; p = 0.0004), while CSglobal was not (p = 1.0). Negative LGE segments demonstrated decreased LSregional in HCM patients compared to in controls (p < 0.0001), while CSregional was not decreased. CSCoV demonstrated the largest area under the curve (AUC) (0.91), with high sensitivity (83%) and specificity (94%) for detection of HCM patients with extensive LGE, while the AUC of LSCoV was low (0.49). CONCLUSION: The heterogeneity in CSregional has a high diagnostic value for detection of HCM patients with extensive LGE.
Entities:
Keywords:
Circumferential strain; Hypertrophic cardiomyopathy; Late gadolinium enhancement; Longitudinal strain; Strain-encoded magnetic resonance imaging
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