BACKGROUND/AIMS: The aim of this study was to explore the relationship between hypertriglyceridemic waist (HW) phenotype and early diabetic nephropathy in type 2 diabetes. METHODS: A cross-sectional study was conducted on 538 type 2 diabetes patients in Qinhuangdao. The HW phenotype was defined as serum triglyceride concentrations ≥1.7 mmol/L and waist circumference ≥90 cm (males) and ≥85 cm (females). RESULTS: The prevalence of the HW phenotype was 34.9%. The prevalence of early diabetic nephropathy was 10.6% in type 2 diabetes patients with normal waist circumference and triglycerides and 24.5% in type 2 diabetes patients with HW phenotype. After adjustment for sex, age, body mass index, hypertension, history of diabetes, and glycosylated hemoglobin A1c, the prevalence of early diabetic nephropathy among type 2 diabetes patients with the HW phenotype was 2.81 (95% confidence interval 1.36-5.80, p = 0.005) times higher than that among type 2 diabetes patients with normal waist circumference and triglycerides. CONCLUSION: There was a significant correlation between HW phenotype and early diabetic nephropathy in type 2 diabetes.
BACKGROUND/AIMS: The aim of this study was to explore the relationship between hypertriglyceridemic waist (HW) phenotype and early diabetic nephropathy in type 2 diabetes. METHODS: A cross-sectional study was conducted on 538 type 2 diabetes patients in Qinhuangdao. The HW phenotype was defined as serum triglyceride concentrations ≥1.7 mmol/L and waist circumference ≥90 cm (males) and ≥85 cm (females). RESULTS: The prevalence of the HW phenotype was 34.9%. The prevalence of early diabetic nephropathy was 10.6% in type 2 diabetes patients with normal waist circumference and triglycerides and 24.5% in type 2 diabetes patients with HW phenotype. After adjustment for sex, age, body mass index, hypertension, history of diabetes, and glycosylated hemoglobin A1c, the prevalence of early diabetic nephropathy among type 2 diabetes patients with the HW phenotype was 2.81 (95% confidence interval 1.36-5.80, p = 0.005) times higher than that among type 2 diabetes patients with normal waist circumference and triglycerides. CONCLUSION: There was a significant correlation between HW phenotype and early diabetic nephropathy in type 2 diabetes.
Entities:
Keywords:
Early diabetic nephropathy; Hypertriglyceridemic waist phenotype; Type 2 diabetes
Authors: Meredith C Foster; Shih-Jen Hwang; Joseph M Massaro; Udo Hoffmann; Ian H DeBoer; Sander J Robins; Ramachandran S Vasan; Caroline S Fox Journal: Obesity (Silver Spring) Date: 2010-12-23 Impact factor: 5.002
Authors: Fleur R de Graaf; Joanne D Schuijf; Arthur J Scholte; Roxana Djaberi; Joella E van Velzen; Cornelis J Roos; Lucia J Kroft; Albert de Roos; Ernst E van der Wall; J Wouter Jukema; Jean-Pierre Després; Jeroen J Bax Journal: Am J Cardiol Date: 2010-10-26 Impact factor: 2.778
Authors: Susana Borruel; José F Moltó; Macarena Alpañés; Elena Fernández-Durán; Francisco Álvarez-Blasco; Manuel Luque-Ramírez; Héctor F Escobar-Morreale Journal: PLoS One Date: 2014-12-05 Impact factor: 3.240
Authors: Haroon Kamran; Eric Kupferstein; Navneet Sharma; Jocelyne G Karam; Alyson K Myers; Irini Youssef; James R Sowers; Deborah R Gustafson; Moro O Salifu; Samy I McFarlane Journal: Cardiorenal Med Date: 2018-01-22 Impact factor: 2.041