| Literature DB >> 29117789 |
Sunny Malhotra1, Melissa Sorosina2, Jordi Río1, Silvia Peroni2, Luciana Midaglia1, Luisa M Villar3, José C Álvarez-Cermeño3, Ina Schroeder4, Federica Esposito5, Ferdinando Clarelli2, Uwe K Zettl4, Jeannette Lechner-Scott6, Nino Spataro7, Arcadi Navarro8, Giancarlo Comi9, Xavier Montalban1, Filippo Martinelli-Boneschi10, Manuel Comabella1.
Abstract
We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.Entities:
Keywords: Multiple sclerosis; inflammasome; interferon-beta; polymorphisms
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Year: 2017 PMID： 29117789 DOI： 10.1177/1352458517739137
Source DB: PubMed Journal: Mult Scler ISSN： 1352-4585 Impact factor: 6.312