Elizabeth Stein1, Waylon Howard1, Ali Rowhani-Rahbar2,3, Frederick P Rivara1,3,4, Douglas Zatzick3,5, Carolyn A McCarty1,4. 1. a Center for Child Health, Behavior and Development , Seattle Children's Research Institute , Seattle , WA, USA. 2. b Department of Epidemiology , University of Washington , Seattle , WA, USA. 3. c Harborview Injury Prevention and Research Center , University of Washington , Seattle , WA, USA. 4. d Department of Pediatrics , University of Washington , Seattle , WA, USA. 5. e Department of Psychiatry and Behavioral Sciences , University of Washington , Seattle , WA, USA.
Abstract
PRIMARY OBJECTIVE: To investigate the symptom trajectories of depressive and post-concussive symptoms (PCS) in slow-to-recover adolescents to understand how the two sets of symptoms are related. RESEARCH DESIGN: We used data from a randomized clinical trial of a collaborative care intervention for post-concussive symptoms to better understand how these two sets of symptoms change in parallel over 6 months. METHODS AND PROCEDURE: PCS and depressive symptom scores for 49 adolescents (ages 11-17) were measured at enrolment and after 1, 3, and 6 months. Latent growth curve modelling for parallel processes was used to simultaneously examine change in PCS and depressive symptoms over time and to evaluate the influence of one change process on the other. MAIN OUTCOMES AND RESULTS: On average, patients enrolled 66 days following injury (Interquartile range (IQR) 43.5, 88.5). PCS and depressive symptoms were significantly associated at enrolment and over time, and both decreased over the course of 6 months. Higher PCS at enrolment predicted a greater decrease in depressive symptoms over time. CONCLUSIONS: Our results suggest that clinicians should screen for and treat depressive symptoms in patients with high post-concussive symptoms one month following injury.
RCT Entities:
PRIMARY OBJECTIVE: To investigate the symptom trajectories of depressive and post-concussive symptoms (PCS) in slow-to-recover adolescents to understand how the two sets of symptoms are related. RESEARCH DESIGN: We used data from a randomized clinical trial of a collaborative care intervention for post-concussive symptoms to better understand how these two sets of symptoms change in parallel over 6 months. METHODS AND PROCEDURE: PCS and depressive symptom scores for 49 adolescents (ages 11-17) were measured at enrolment and after 1, 3, and 6 months. Latent growth curve modelling for parallel processes was used to simultaneously examine change in PCS and depressive symptoms over time and to evaluate the influence of one change process on the other. MAIN OUTCOMES AND RESULTS: On average, patients enrolled 66 days following injury (Interquartile range (IQR) 43.5, 88.5). PCS and depressive symptoms were significantly associated at enrolment and over time, and both decreased over the course of 6 months. Higher PCS at enrolment predicted a greater decrease in depressive symptoms over time. CONCLUSIONS: Our results suggest that clinicians should screen for and treat depressive symptoms in patients with high post-concussive symptoms one month following injury.
Authors: Robin L Peterson; Michael W Kirkwood; H Gerry Taylor; Terry Stancin; Tanya M Brown; Shari L Wade Journal: J Head Trauma Rehabil Date: 2013 Sep-Oct Impact factor: 2.710
Authors: Heidi Losoi; Noah D Silverberg; Minna Wäljas; Senni Turunen; Eija Rosti-Otajärvi; Mika Helminen; Teemu M Luoto; Juhani Julkunen; Juha Öhman; Grant L Iverson Journal: J Neurotrauma Date: 2015-12-17 Impact factor: 5.269
Authors: Clinton D Morgan; Scott L Zuckerman; Young M Lee; Lauren King; Susan Beaird; Allen K Sills; Gary S Solomon Journal: J Neurosurg Pediatr Date: 2015-03-06 Impact factor: 2.375
Authors: Roger Zemek; Nick Barrowman; Stephen B Freedman; Jocelyn Gravel; Isabelle Gagnon; Candice McGahern; Mary Aglipay; Gurinder Sangha; Kathy Boutis; Darcy Beer; William Craig; Emma Burns; Ken J Farion; Angelo Mikrogianakis; Karen Barlow; Alexander S Dubrovsky; Willem Meeuwisse; Gerard Gioia; William P Meehan; Miriam H Beauchamp; Yael Kamil; Anne M Grool; Blaine Hoshizaki; Peter Anderson; Brian L Brooks; Keith Owen Yeates; Michael Vassilyadi; Terry Klassen; Michelle Keightley; Lawrence Richer; Carol DeMatteo; Martin H Osmond Journal: JAMA Date: 2016-03-08 Impact factor: 56.272
Authors: Kelly Sarmiento; Gerard A Gioia; Michael W Kirkwood; Shari L Wade; Keith O Yeates Journal: Clin Neuropsychol Date: 2019-09-18 Impact factor: 3.535
Authors: Elena Sheldrake; Hiba Al-Hakeem; Brendan Lam; Benjamin I Goldstein; Anne L Wheeler; Matthew Burke; Benjamin T Dunkley; Nick Reed; Shannon E Scratch Journal: Front Neurol Date: 2022-04-11 Impact factor: 4.086
Authors: Emily M Robinson; Sananthan Sivakanthan; Sharon Durfy; Frederick P Rivara; Sara Chrisman; Christine L Mac Donald Journal: Cureus Date: 2022-08-29
Authors: Adam C Raikes; Gerson D Hernandez; Veronica A Mullins; Yiwei Wang; Claudia Lopez; William D S Killgore; Floyd H Chilton; Roberta D Brinton Journal: Front Neurol Date: 2022-09-15 Impact factor: 4.086