Literature DB >> 29114815

Maternal Use of Antiepileptic Agents During Pregnancy and Major Congenital Malformations in Children.

Rebecca L Bromley1,2, Jennifer Weston3, Anthony G Marson4,5.   

Abstract

CLINICAL QUESTION: Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children? BOTTOM LINE: Certain antiepileptic drugs were associated with increased rates of congenital malformations (eg, spina bifida, cardiac anomalies). Lamotrigine (2.31% in 4195 pregnancies) and levetiracetam (1.77% in 817 pregnancies) were associated with the lowest risk and valproate was associated with the highest risk (10.93% in 2565 pregnancies) compared with the offspring of women without epilepsy (2.51% in 2154 pregnancies).

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Year:  2017        PMID： 29114815     DOI： 10.1001/jama.2017.14485

Source DB:  PubMed          Journal:  JAMA        ISSN： 0098-7484            Impact factor:   56.272


  12 in total

Review 1.  Pharmacological Management of the Genetic Generalised Epilepsies in Adolescents and Adults.

Authors:  Linda J Stephen; Martin J Brodie
Journal:  CNS Drugs       Date:  2020-02       Impact factor: 5.749

2.  Structure-Activity Relationship (SAR) Model for Predicting Teratogenic Risk of Antiseizure Medications in Pregnancy by Using Support Vector Machine.

Authors:  Liyuan Kang; Yifei Duan; Cheng Chen; Shihai Li; Menglong Li; Lei Chen; Zhining Wen
Journal:  Front Pharmacol       Date:  2022-02-25       Impact factor: 5.810

Review 3.  Targeted drug delivery for maternal and perinatal health: Challenges and opportunities.

Authors:  Anjali Sharma; Nirnath Sah; Sujatha Kannan; Rangaramanujam M Kannan
Journal:  Adv Drug Deliv Rev       Date:  2021-08-26       Impact factor: 17.873

4.  Cross-sectional evaluation of prescription of valproate and other antiepileptic drugs to pregnant women.

Authors:  Duygun Altıntaş Aykan; Yusuf Ergün
Journal:  Acta Neurol Belg       Date:  2019-10-28       Impact factor: 2.396

5.  Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation.

Authors:  Johannes Meisig; Nadine Dreser; Marion Kapitza; Margit Henry; Tamara Rotshteyn; Jörg Rahnenführer; Jan G Hengstler; Agapios Sachinidis; Tanja Waldmann; Marcel Leist; Nils Blüthgen
Journal:  Nucleic Acids Res       Date:  2020-12-16       Impact factor: 16.971

Review 6.  Expert opinion: use of valproate in girls and women of childbearing potential with epilepsy: recommendations and alternatives based on a review of the literature and clinical experience-a European perspective.

Authors:  Manuel Toledo; Barbara Mostacci; Magdalena Bosak; Joanna Jedrzejzak; Rhys H Thomas; Javier Salas-Puig; Arnaud Biraben; Bettina Schmitz
Journal:  J Neurol       Date:  2020-04-01       Impact factor: 4.849

Review 7.  Anaesthesia and neurological disorders in pregnancy.

Authors:  Y Metodiev; F Braveman
Journal:  BJA Educ       Date:  2021-03-18

8.  Molecular Basis of Spina Bifida: Recent Advances and Future Prospectives.

Authors:  Prateek Kumar Panda; Kanhu Charan Mallik; Ranjankumar Patel; Mayadhar Barik
Journal:  J Pediatr Neurosci       Date:  2019 Jan-Mar

9.  Psychiatric comorbidities, sexual health and neurodevelopmental outcomes of offspring in men with epilepsy.

Authors:  Marc Casale; Hernan Nicolas Lemus; James J Young; Lara V Marcuse; Ji Yeoun Yoo; Svetlana Faktorovich; Bridget Mueller; Madeline C Fields
Journal:  Epilepsy Behav       Date:  2020-11-24       Impact factor: 2.937

10.  Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring.

Authors:  Jakob Christensen; Lars Pedersen; Yuelian Sun; Julie Werenberg Dreier; Isabell Brikell; Søren Dalsgaard
Journal:  JAMA Netw Open       Date:  2019-01-04
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