Literature DB >> 29113604

Tau accumulation in two patients with frontotemporal lobe degeneration showing different types of aphasia using 18F-THK-5351 positron emission tomography: a case report.

Masahiko Takaya1, Kazunari Ishii2, Chisa Hosokawa2, Kazumasa Saigoh3, Osamu Shirakawa1.   

Abstract

ABSTRACTTau deposits in Alzheimer's disease and corticobasal syndrome have been reported using 18F-THK-5351 positron emission tomography (PET). To our knowledge, our study is the first to demonstrate tau deposits in patients with frontotemporal lobe degeneration (FTLD), using 18F-THK-5351 PET. This case report presents two patients, both of whom showed positive Tau deposition using 18F-THK-5351 PET. One patient was diagnosed with semantic variant primary progressive aphasia (PPA) and the other diagnosed with logopenic variant PPA. Our results suggest an association in the pathology of Alzheimer's disease, corticobasal syndrome, and FTLD, and could plan more effective clinical care in advance.

Entities:  

Keywords:  18F-THK-5351 PET; Tau; frontotemporal lobe degeneration; logopenic aphasia; semantic dementia

Mesh：

Substances：

Year:  2017        PMID： 29113604     DOI： 10.1017/S1041610217002277

Source DB:  PubMed          Journal:  Int Psychogeriatr        ISSN： 1041-6102            Impact factor:   3.878


  5 in total

Review 1.  Clinical validity of increased cortical binding of tau ligands of the THK family and PBB3 on PET as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework.

Authors:  Konstantinos Chiotis; Alessandra Dodich; Marina Boccardi; Cristina Festari; Alexander Drzezga; Oskar Hansson; Rik Ossenkoppele; Giovanni Frisoni; Valentina Garibotto; Agneta Nordberg
Journal:  Eur J Nucl Med Mol Imaging       Date:  2021-03-15       Impact factor: 9.236

2.  Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants.

Authors:  Jolien Schaeverbeke; Charlotte Evenepoel; Lieven Declercq; Silvy Gabel; Karen Meersmans; Rose Bruffaerts; Kate Adamczuk; Eva Dries; Karen Van Bouwel; Anne Sieben; Yolande Pijnenburg; Ronald Peeters; Guy Bormans; Koen Van Laere; Michel Koole; Patrick Dupont; Rik Vandenberghe
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-06-26       Impact factor: 9.236

Review 3.  Imaging of Reactive Astrogliosis by Positron Emission Tomography.

Authors:  Ryuichi Harada; Shozo Furumoto; Yukitsuka Kudo; Kazuhiko Yanai; Victor L Villemagne; Nobuyuki Okamura
Journal:  Front Neurosci       Date:  2022-02-08       Impact factor: 4.677

Review 4.  [18F]THK-5351 PET imaging in early-stage semantic variant primary progressive aphasia: a report of two cases and a literature review.

Authors:  Ryota Kobayashi; Hiroshi Hayashi; Shinobu Kawakatsu; Aiko Ishiki; Nobuyuki Okamura; Hiroyuki Arai; Koichi Otani
Journal:  BMC Neurol       Date:  2018-08-08       Impact factor: 2.474

Review 5.  The development and validation of tau PET tracers: current status and future directions.

Authors:  Nobuyuki Okamura; Ryuichi Harada; Aiko Ishiki; Akio Kikuchi; Tadaho Nakamura; Yukitsuka Kudo
Journal:  Clin Transl Imaging       Date:  2018-07-20
  5 in total

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