| Literature DB >> 29112847 |
Matthew C Lorincz1, Dirk Schübeler2.
Abstract
CpG island promoters are generally devoid of DNA methylation in somatic cells but are frequently methylated during tumorigenesis. Reporting recently in Nature, Smith et al. (2017) show that the signaling-induced methylome in early extraembryonic tissues resembles that of many cancers, suggesting that placental nuclear programming might be co-opted in tumorigenesis.Entities:
Mesh:
Year: 2017 PMID: 29112847 DOI: 10.1016/j.devcel.2017.10.009
Source DB: PubMed Journal: Dev Cell ISSN: 1534-5807 Impact factor: 12.270