Literature DB >> 29112431

Pleiokomenines A and B: Dimeric Aspidofractinine Alkaloids Tethered with a Methylene Group.

Elvis Otogo N'Nang Obiang1,2, Grégory Genta-Jouve3, Jean-François Gallard4, Brice Kumulungui2, Elisabeth Mouray5, Philippe Grellier5, Laurent Evanno1, Erwan Poupon1, Pierre Champy1, Mehdi A Beniddir1.   

Abstract

Pleiokomenines A and B (1 and 2), first examples of dimeric aspidofractinine alkaloids linked by a methylene bridge, were isolated from the stem bark of Pleiocarpa mutica. Their structures were elucidated by a combination of spectroscopic analyses and semisynthetic derivatization of pleiocarpinine (3) and a formaldehyde equivalent mediated by scandium trifluoromethanesulfonate. Pleiokomenines A (1) and B (2) showed moderate antiplasmodial activities in the micromolar range against the FcB1 strain.

Entities:  

Year:  2017        PMID： 29112431     DOI： 10.1021/acs.orglett.7b03098

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Collected mass spectrometry data on monoterpene indole alkaloids from natural product chemistry research.

Authors:  Alexander E Fox Ramos; Pierre Le Pogam; Charlotte Fox Alcover; Elvis Otogo N'Nang; Gaëla Cauchie; Hazrina Hazni; Khalijah Awang; Dimitri Bréard; Antonio M Echavarren; Michel Frédérich; Thomas Gaslonde; Marion Girardot; Raphaël Grougnet; Mariia S Kirillova; Marina Kritsanida; Christelle Lémus; Anne-Marie Le Ray; Guy Lewin; Marc Litaudon; Lengo Mambu; Sylvie Michel; Fedor M Miloserdov; Michael E Muratore; Pascal Richomme-Peniguel; Fanny Roussi; Laurent Evanno; Erwan Poupon; Pierre Champy; Mehdi A Beniddir
Journal:  Sci Data       Date:  2019-04-03       Impact factor: 6.444

2.  Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras.

Authors:  Tapé Kouamé; Aboua Timothée Okpekon; Nicaise F Bony; Amon Diane N'Tamon; Jean-François Gallard; Somia Rharrabti; Karine Leblanc; Elisabeth Mouray; Philippe Grellier; Pierre Champy; Mehdi A Beniddir; Pierre Le Pogam
Journal:  Molecules       Date:  2020-06-07       Impact factor: 4.411
  2 in total

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