Po-Hong Liu1,2, Yin Cao2,3,4,5, Brieze R Keeley6, Idy Tam7, Kana Wu4, Lisa L Strate8, Edward L Giovannucci1,4,9, Andrew T Chan1,2,3,10. 1. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. 2. Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. 3. Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. 4. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. 5. Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA. 6. Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. 7. Tufts University School of Medicine, Boston, Massachusetts, USA. 8. Division of Gastroenterology, Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle, Washington, USA. 9. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 10. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Abstract
OBJECTIVES: Diverticulitis is a common disease with high clinical burden. We evaluated the joint contribution of multiple lifestyle factors to risks of incident diverticulitis. We also estimated the proportion of diverticulitis preventable by lifestyle modifications. METHODS: We prospectively examined the association between lifestyle factors (red meat, dietary fiber intake, vigorous physical activity (activity with metabolic equivalent ≥6), body mass index (BMI), and smoking) and risk of diverticulitis among participants in the Health Professionals Follow-Up Study. RESULTS: We documented 907 incident cases of diverticulitis during 757,791 person-years. High intake of red meat, low intake of dietary fiber, low vigorous physical activity, high BMI, and smoking were independently associated with increased risks of diverticulitis (all P<0.05). Low-risk lifestyle was defined as average red meat intake <51 g per day, dietary fiber intake in the top 40% of the cohort (about 23 g per day), vigorous physical activity in the highest 50% among participants with non-zero vigorous physical activity (roughly 2 h of exercise weekly), normal BMI between 18.5-24.9 kg m-2, and never-smoker. There was an inverse linear relationship between number of low-risk lifestyle factors and diverticulitis incidence (P for trend<0.001). Compared with men with no low-risk lifestyle factors, the multivariable relative risks of diverticulitis were 0.71 (95% confidence interval (CI): 0.59-0.87) for men with 1 low-risk lifestyle factor; 0.66 (95% CI: 0.55-0.81) for 2 low-risk factors; 0.50 (95% CI: 0.40-0.62) for 3 low-risk factors; 0.47 (95% CI: 0.35-0.62) for 4 low-risk factors, and 0.27 (95% CI: 0.15-0.48) for 5 low-risk factors. Adherence to a low-risk lifestyle could prevent 50% (95% CI: 20-71%) of incident diverticulitis. CONCLUSIONS: Adherence to a low-risk lifestyle is associated with reduced incidence of diverticulitis.
OBJECTIVES:Diverticulitis is a common disease with high clinical burden. We evaluated the joint contribution of multiple lifestyle factors to risks of incident diverticulitis. We also estimated the proportion of diverticulitis preventable by lifestyle modifications. METHODS: We prospectively examined the association between lifestyle factors (red meat, dietary fiber intake, vigorous physical activity (activity with metabolic equivalent ≥6), body mass index (BMI), and smoking) and risk of diverticulitis among participants in the Health Professionals Follow-Up Study. RESULTS: We documented 907 incident cases of diverticulitis during 757,791 person-years. High intake of red meat, low intake of dietary fiber, low vigorous physical activity, high BMI, and smoking were independently associated with increased risks of diverticulitis (all P<0.05). Low-risk lifestyle was defined as average red meat intake <51 g per day, dietary fiber intake in the top 40% of the cohort (about 23 g per day), vigorous physical activity in the highest 50% among participants with non-zero vigorous physical activity (roughly 2 h of exercise weekly), normal BMI between 18.5-24.9 kg m-2, and never-smoker. There was an inverse linear relationship between number of low-risk lifestyle factors and diverticulitis incidence (P for trend<0.001). Compared with men with no low-risk lifestyle factors, the multivariable relative risks of diverticulitis were 0.71 (95% confidence interval (CI): 0.59-0.87) for men with 1 low-risk lifestyle factor; 0.66 (95% CI: 0.55-0.81) for 2 low-risk factors; 0.50 (95% CI: 0.40-0.62) for 3 low-risk factors; 0.47 (95% CI: 0.35-0.62) for 4 low-risk factors, and 0.27 (95% CI: 0.15-0.48) for 5 low-risk factors. Adherence to a low-risk lifestyle could prevent 50% (95% CI: 20-71%) of incident diverticulitis. CONCLUSIONS: Adherence to a low-risk lifestyle is associated with reduced incidence of diverticulitis.
Authors: Lisa L Strate; Yan L Liu; Edward S Huang; Edward L Giovannucci; Andrew T Chan Journal: Gastroenterology Date: 2011-02-12 Impact factor: 22.682
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Authors: Manol Jovani; Wenjie Ma; Amit D Joshi; Po-Hong Liu; Long H Nguyen; Yin Cao; Idy Tam; Kana Wu; Edward L Giovannucci; Andrew T Chan; Lisa L Strate Journal: Am J Gastroenterol Date: 2019-02 Impact factor: 10.864
Authors: Wenjie Ma; Long H Nguyen; Mingyang Song; Manol Jovani; Po-Hong Liu; Yin Cao; Idy Tam; Kana Wu; Edward L Giovannucci; Lisa L Strate; Andrew T Chan Journal: Am J Gastroenterol Date: 2019-09 Impact factor: 10.864