Qingzhong Wang1,2,3,4, Weidong Ji2,3, Kuanjun He2, Zhiqiang Li2, Jianhua Chen1,2,3,4, Wenjin Li2, Zujia Wen2, Jiawei Shen2, Qiang Yu2, Guoyin Feng4, Jue Ji2, Yujiong Wang5,6, Yongyong Shi1,2,3,6. 1. Institute of Social Cognitive and Behavioral Sciences. 2. Bio-X Institutes and Affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education). 3. Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University. 4. Shanghai Institute of Mental Health, Shanghai. 5. Key Laboratory of Ministry of Education for Conservation and Utilization of Special eBiological Resources in the Western. 6. College of Life Science, Ningxia University, Yinchuan, Ningxia, People's Republic of China.
Abstract
AIM/OBJECTIVES/ BACKGROUND: ZNF804A has been investigated widely as a candidate susceptibility gene for mental disorders in individuals of different ethnicities. However, in the Han Chinese population, most studies of this gene have focused on associations of the common single nucleotide polymorphism (SNP) rs1344706. METHODS: To investigate additional common variants within ZNF804A, we carried out a case-control study of 13 SNPs distributed across the whole gene, in 1330 schizophrenic patients, 1045 major depressive disorder patients, and 1235 normal controls. RESULTS AND CONCLUSIONS: We found that rs12476147 (P=0.0078) was associated significantly with schizophrenia, but no SNPs showed statistically significant associations with major depressive disorder after Bonferroni correction. Moreover, we also found that haplotype block 2, which included rs12476147 and rs1344706, was associated significantly with schizophrenia and major depressive disorder. Nevertheless, we could not replicate the association of rs1344706 with schizophrenia. In conclusion, the common variant rs12476147 and the related haplotype block in ZNF804A were associated significantly with schizophrenia in the Han Chinese population.
AIM/OBJECTIVES/ BACKGROUND:ZNF804A has been investigated widely as a candidate susceptibility gene for mental disorders in individuals of different ethnicities. However, in the Han Chinese population, most studies of this gene have focused on associations of the common single nucleotide polymorphism (SNP) rs1344706. METHODS: To investigate additional common variants within ZNF804A, we carried out a case-control study of 13 SNPs distributed across the whole gene, in 1330 schizophrenicpatients, 1045 major depressive disorderpatients, and 1235 normal controls. RESULTS AND CONCLUSIONS: We found that rs12476147 (P=0.0078) was associated significantly with schizophrenia, but no SNPs showed statistically significant associations with major depressive disorder after Bonferroni correction. Moreover, we also found that haplotype block 2, which included rs12476147 and rs1344706, was associated significantly with schizophrenia and major depressive disorder. Nevertheless, we could not replicate the association of rs1344706 with schizophrenia. In conclusion, the common variant rs12476147 and the related haplotype block in ZNF804A were associated significantly with schizophrenia in the Han Chinese population.
Authors: Gema Requena; Victoria Banks; Alexandrosz Czira; Robert Wood; Theo Tritton; Rosie Wild; Chris Compton; Maria Duarte; Afisi S Ismaila Journal: Int J Chron Obstruct Pulmon Dis Date: 2022-08-10