Literature DB >> 29112074

Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants.

Kristin Beima-Sofie1, Dalton Wamalwa2, Elizabeth Maleche-Obimbo2, Jairam R Lingappa1,3,4, Romel Mackelprang1, Soren Gantt5, Grace John-Stewart1,3,4,6, Corey Casper1,3,7, Jennifer A Slyker1,6.   

Abstract

: Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P = 0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (hazard ratio = 4.2, P = 0.02) compared with 1635GG. In addition, 1635A was associated with 0.4 log10 copies/ml lower median EBV levels in HIV-infected infants (P = 0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.

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Year:  2018        PMID： 29112074      PMCID： PMC5736409          DOI： 10.1097/QAD.0000000000001680

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  25 in total

1.  Prospective Characterization of the Risk Factors for Transmission and Symptoms of Primary Human Herpesvirus Infections Among Ugandan Infants.

Authors:  Soren Gantt; Jackson Orem; Elizabeth M Krantz; Rhoda Ashley Morrow; Stacy Selke; Meei-Li Huang; Joshua T Schiffer; Keith R Jerome; Annet Nakaganda; Anna Wald; Corey Casper; Lawrence Corey
Journal:  J Infect Dis       Date:  2016-02-24       Impact factor: 5.226

2.  Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group.

Authors:  A Kovacs; M Schluchter; K Easley; G Demmler; W Shearer; P La Russa; J Pitt; E Cooper; J Goldfarb; D Hodes; M Kattan; K McIntosh
Journal:  N Engl J Med       Date:  1999-07-08       Impact factor: 91.245

Review 3.  Genetic variation in Toll-like receptors and disease susceptibility.

Authors:  Mihai G Netea; Cisca Wijmenga; Luke A J O'Neill
Journal:  Nat Immunol       Date:  2012-05-18       Impact factor: 25.606

4.  Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection.

Authors:  Pierre-Yves Bochud; Martin Hersberger; Patrick Taffé; Murielle Bochud; Catherine M Stein; Stephanie D Rodrigues; Thierry Calandra; Patrick Francioli; Amalio Telenti; Roberto F Speck; Alan Aderem
Journal:  AIDS       Date:  2007-02-19       Impact factor: 4.177

5.  Clinical and virologic manifestations of primary Epstein-Barr virus (EBV) infection in Kenyan infants born to HIV-infected women.

Authors:  Jennifer A Slyker; Corey Casper; Kenneth Tapia; Barbra Richardson; Lisa Bunts; Meei-Li Huang; Elizabeth Maleche-Obimbo; Ruth Nduati; Grace John-Stewart
Journal:  J Infect Dis       Date:  2013-03-14       Impact factor: 5.226

Review 6.  Spectrum of Epstein-Barr virus-associated diseases.

Authors:  J L Kutok; F Wang
Journal:  Annu Rev Pathol       Date:  2006       Impact factor: 23.472

7.  Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals.

Authors:  Samuel O Pine; M Juliana McElrath; Pierre-Yves Bochud
Journal:  AIDS       Date:  2009-11-27       Impact factor: 4.177

8.  HV-1-specific cytotoxic T lymphocytes and breast milk HIV-1 transmission.

Authors:  Grace C John-Stewart; Dorothy Mbori-Ngacha; Barbara Lohman Payne; Carey Farquhar; Barbra A Richardson; Sandra Emery; Phelgona Otieno; Elizabeth Obimbo; Tao Dong; Jennifer Slyker; Ruth Nduati; Julie Overbaugh; Sarah Rowland-Jones
Journal:  J Infect Dis       Date:  2009-03-15       Impact factor: 5.226

9.  Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level.

Authors:  Kristin M Beima-Sofie; Abigail W Bigham; Jairam R Lingappa; Dalton Wamalwa; Romel D Mackelprang; Michael J Bamshad; Elizabeth Maleche-Obimbo; Barbra A Richardson; Grace C John-Stewart
Journal:  AIDS       Date:  2013-09-24       Impact factor: 4.177

10.  TLR9 2848 GA heterozygotic status possibly predisposes fetuses and newborns to congenital infection with human cytomegalovirus.

Authors:  Wioletta Wujcicka; Edyta Paradowska; Mirosława Studzińska; Zuzanna Gaj; Jan Wilczyński; Zbigniew Leśnikowski; Dorota Nowakowska
Journal:  PLoS One       Date:  2015-04-06       Impact factor: 3.240
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  2 in total

Review 1.  Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections.

Authors:  Marta Maria Gaglia
Journal:  Virol J       Date:  2021-11-08       Impact factor: 4.099

Review 2.  High-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis.

Authors:  Rancés Blanco; Diego Carrillo-Beltrán; Alejandro H Corvalán; Francisco Aguayo
Journal:  Biology (Basel)       Date:  2021-11-26
  2 in total

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