Jochen Schmitt1, Eva Haufe, Freya Trautmann, Hans-Joachim Schulze, Peter Elsner, Hans Drexler, Andrea Bauer, Stephan Letzel, Swen Malte John, Manigé Fartasch, Thomas Brüning, Andreas Seidler, Susanne Dugas-Breit, Michal Gina, Wobbeke Weistenhöfer, Klaus Bachmann, Ilka Bruhn, Berenice Mareen Lang, Sonja Bonness, Jean Pierre Allam, William Grobe, Thoralf Stange, Stephan Westerhausen, Peter Knuschke, Marc Wittlich, Thomas Ludwig Diepgen. 1. Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Dr Schmitt, Dr Haufe, Trautmann, Stange); Institute and Outpatient Clinics of Occupational and Social Medicine, Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Drs Haufe, Andreas Seidler); Department of Dermatology, Dermatological Radiotherapy and Dermatohistopathology, Special Clinics Hornheide, Münster, Germany (Drs Schulze, Dugas-Breit); Department of Dermatology, University Hospital Jena, Jena, Germany (Drs Elsner, Gina); Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-University, Erlangen-Nürnberg, Germany (Drs Drexler, Weistenhöfer); Department of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Drs Bauer, Bruhn); Institute of Occupational, Social and Environmental Medicine, University Medical Center, Johannes-Gutenberg University, Mainz, Germany (Dr Letzel); Department of Dermatology, Environmental Health and Health Theory, University of Osnabrück and Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany (Dr John); Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (DGUV), Institute of Ruhr-University Bochum (IPA), Bochum, Germany (Drs Fartasch, Brüning); Department of Clinical Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Heidelberg, Germany (Drs Bachmann, Diepgen); Department of Dermatology, University Medical Center, Johannes-Gutenberg University, Mainz, Germany (Dr Lang); Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Employer's Liability Insurance Association Clinics Hamburg, Hamburg, Germany (Dr Bonness); Department of Dermatology and Allergy, University Bonn, Bonn, Germany (Drs Allam, Grobe); Department of Radiation, Institute of Occupational Health and Safety of the German Social Accident Insurance (DGUV), Sankt Augustin, Germany (Westerhausen, Dr Wittlich); and Department of Dermatology, Experimental Photobiology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany (Knuschke).
Abstract
OBJECTIVE: The aim of this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development of basal cell carcinoma (BCC). METHODS: We undertook a population-based multicenter case-control study. Patients with first incident BCC (n = 836) were propensity score matched by age and sex to controls without skin cancer (n = 836). Sociodemographic characteristics, clinical characteristics, and lifetime UV-exposure were assessed by trained investigators. The differential estimation of occupational and nonoccupational UV-exposure dosages was based on validated instruments and established reference values. Associations were assessed using multivariable-adjusted conditional logistic regression models. RESULTS: Individuals with high levels of occupational UV-exposure were at significantly increased BCC-risk compared with individuals with low [odds ratio (OR) 1.84; 95% confidence interval (95% CI) 1.19 to 2.83 and moderate (OR 1.97; 95% CI 1.20 to 3.22) occupational UV-exposure. Nonoccupational UV-exposure was not independently associated with BCC. CONCLUSION: Skin cancer prevention strategies should be expanded to the occupational setting.
OBJECTIVE: The aim of this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development of basal cell carcinoma (BCC). METHODS: We undertook a population-based multicenter case-control study. Patients with first incident BCC (n = 836) were propensity score matched by age and sex to controls without skin cancer (n = 836). Sociodemographic characteristics, clinical characteristics, and lifetime UV-exposure were assessed by trained investigators. The differential estimation of occupational and nonoccupational UV-exposure dosages was based on validated instruments and established reference values. Associations were assessed using multivariable-adjusted conditional logistic regression models. RESULTS: Individuals with high levels of occupational UV-exposure were at significantly increased BCC-risk compared with individuals with low [odds ratio (OR) 1.84; 95% confidence interval (95% CI) 1.19 to 2.83 and moderate (OR 1.97; 95% CI 1.20 to 3.22) occupational UV-exposure. Nonoccupational UV-exposure was not independently associated with BCC. CONCLUSION:Skin cancer prevention strategies should be expanded to the occupational setting.
Authors: Cheryl E Peters; J Kim; C Song; E Heer; V H Arrandale; M Pahwa; F Labrèche; C B McLeod; H W Davies; C B Ge; P A Demers Journal: Int Arch Occup Environ Health Date: 2019-07-03 Impact factor: 3.015
Authors: A Bauer; E Haufe; L Heinrich; A Seidler; H J Schulze; P Elsner; H Drexler; S Letzel; S M John; M Fartasch; T Brüning; S Dugas-Breit; M Gina; W Weistenhöfer; K Bachmann; I Bruhn; B M Lang; R Brans; J P Allam; W Grobe; S Westerhausen; P Knuschke; M Wittlich; T L Diepgen; J Schmitt Journal: J Occup Med Toxicol Date: 2020-09-10 Impact factor: 2.646
Authors: Alberto Modenese; Tom Loney; Marc Rocholl; Cara Symanzik; Fabriziomaria Gobba; Swen Malte John; Kurt Straif; Marilia Silva Paulo Journal: Front Public Health Date: 2021-11-11
Authors: Marc Rocholl; Patricia Weinert; Stephan Bielfeldt; Sabrina Laing; Klaus Peter Wilhelm; Claas Ulrich; Swen Malte John Journal: J Occup Med Toxicol Date: 2021-07-05 Impact factor: 2.646