Yukako Tatsumi1, Akiko Morimoto2, Kei Asayama3, Nao Sonoda4, Naomi Miyamatsu5, Yuko Ohno6, Yoshihiro Miyamoto7, Satoshi Izawa8, Takayoshi Ohkubo9. 1. Department of Hygiene and Public Health, Teikyo University School of Medicine, Itabashi, Japan; Department of Preventive Medicine and Epidemiology Informatics, National Cerebral and Cardiovascular Center, Suita, Japan; Department of Clinical Nursing, Shiga University of Medical Science, Otsu, Japan. Electronic address: y.tatsumi@med.teikyo-u.ac.jp. 2. Department of Fundamental Nursing, Graduate School of Nursing, Osaka Prefecture University, Habikino, Japan. Electronic address: morimotoakiko@nursing.osakafu-u.ac.jp. 3. Department of Hygiene and Public Health, Teikyo University School of Medicine, Itabashi, Japan. Electronic address: kei.asayama@med.teikyo-u.ac.jp. 4. Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Japan. Electronic address: 25b16803@sahs.med.osaka-u.ac.jp. 5. Department of Clinical Nursing, Shiga University of Medical Science, Otsu, Japan. Electronic address: miyan@belle.shiga-med.ac.jp. 6. Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Japan. Electronic address: ohno@sahs.med.osaka-u.ac.jp. 7. Department of Preventive Medicine and Epidemiology Informatics, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address: miyamoty@hsp.ncvc.go.jp. 8. Saku Central Hospital, Saku, Japan. Electronic address: ctroffice@sakuhp.or.jp. 9. Department of Hygiene and Public Health, Teikyo University School of Medicine, Itabashi, Japan. Electronic address: tohkubo@med.teikyo-u.ac.jp.
Abstract
AIMS: To investigate the effect of alcohol consumption on impaired insulin secretion and insulin resistance in Japanese. METHODS: The participants in this 5-year cohort study were 2100 Japanese aged 30-74 years without type 2 diabetes mellitus, impaired insulin secretion, or insulin resistance who underwent a medical checkup including 75-g OGTT between April 2008 and March 2009 at Saku Central Hospital. Alcohol consumption was categorized as follows: non-drinker (0 g/week), light drinker (1-139 g/week in men and 1-69 g/week in women), moderate drinker (140-274 g/week in men and 70-139 g/week in women) and heavy drinker (≥275 g/week in men and ≥140 g/week in women). The hazard ratios (HRs) and 95% CIs among light to heavy drinkers for incidence of impaired insulin secretion (insulinogenic index ≤51.7) and insulin resistance (HOMA-IR ≥ 2.5), detected by an OGTT at the time of a follow-up medical checkup before the end of March 2014, were estimated by multivariable adjusted Cox proportional hazard models as reference values for non-drinkers. RESULTS: There were 708 cases of impaired insulin secretion and 191 cases of insulin resistance. The HRs (95% CIs) for impaired insulin secretion in light, moderate and heavy drinkers were 1.16 (0.96-1.40), 1.35 (1.07-1.70) and 1.64 (1.24-2.16), respectively (P for trend <0.001). For insulin resistance, the HRs were 1.22 (0.84-1.76), 1.42 (0.91-2.22) and 1.59 (0.96-2.65), respectively (P for trend = 0.044). CONCLUSION: Alcohol consumption was positively associated with the incidence of both impaired insulin secretion and insulin resistance.
AIMS: To investigate the effect of alcohol consumption on impaired insulin secretion and insulin resistance in Japanese. METHODS: The participants in this 5-year cohort study were 2100 Japanese aged 30-74 years without type 2 diabetes mellitus, impaired insulin secretion, or insulin resistance who underwent a medical checkup including 75-g OGTT between April 2008 and March 2009 at Saku Central Hospital. Alcohol consumption was categorized as follows: non-drinker (0 g/week), light drinker (1-139 g/week in men and 1-69 g/week in women), moderate drinker (140-274 g/week in men and 70-139 g/week in women) and heavy drinker (≥275 g/week in men and ≥140 g/week in women). The hazard ratios (HRs) and 95% CIs among light to heavy drinkers for incidence of impaired insulin secretion (insulinogenic index ≤51.7) and insulin resistance (HOMA-IR ≥ 2.5), detected by an OGTT at the time of a follow-up medical checkup before the end of March 2014, were estimated by multivariable adjusted Cox proportional hazard models as reference values for non-drinkers. RESULTS: There were 708 cases of impaired insulin secretion and 191 cases of insulin resistance. The HRs (95% CIs) for impaired insulin secretion in light, moderate and heavy drinkers were 1.16 (0.96-1.40), 1.35 (1.07-1.70) and 1.64 (1.24-2.16), respectively (P for trend <0.001). For insulin resistance, the HRs were 1.22 (0.84-1.76), 1.42 (0.91-2.22) and 1.59 (0.96-2.65), respectively (P for trend = 0.044). CONCLUSION:Alcohol consumption was positively associated with the incidence of both impaired insulin secretion and insulin resistance.
Authors: Rebecca G Kim; Jonathan Kramer-Feldman; Peter Bacchetti; Barbara Grimes; Esteban Burchard; Celeste Eng; Donglei Hu; Marc Hellerstein; Mandana Khalili Journal: Alcohol Clin Exp Res Date: 2021-11-23 Impact factor: 3.455