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Literature DB >> 29111220

PD-1^hiCXCR5^-CD4⁺ T_FH Cells Play Defense in Cancer and Offense in Arthritis.

Chunyan Gu-Trantien¹, Karen Willard-Gallo².

Abstract

T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1hiCXCR5-CD4+ T cells were recently identified in breast cancer (BC) and rheumatoid arthritis (RA) to have beneficial or detrimental roles, respectively, but are they inflammatory tissue effector TFH cells?

Entities: Disease Gene

Keywords: CXCL13; CXCR5; PD-1; T follicular helper cells; breast cancer; rheumatoid arthritis

Mesh：

Substances：

Year: 2017 PMID： 29111220 DOI： 10.1016/j.it.2017.10.003

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

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Cited

8 in total

1. Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity.

Authors: Grégory Noël; Mireille Langouo Fontsa; Soizic Garaud; Pushpamali De Silva; Alexandre de Wind; Gert G Van den Eynden; Roberto Salgado; Anaïs Boisson; Hanne Locy; Noémie Thomas; Cinzia Solinas; Edoardo Migliori; Céline Naveaux; Hugues Duvillier; Sophie Lucas; Ligia Craciun; Kris Thielemans; Denis Larsimont; Karen Willard-Gallo
Journal: J Clin Invest Date: 2021-10-01 Impact factor: 14.808

Review 2. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy.

Authors: Daniela Bruni; Helen K Angell; Jérôme Galon
Journal: Nat Rev Cancer Date: 2020-08-04 Impact factor: 60.716

3. Circulating Follicular Helper and Follicular Regulatory T Cells Are Severely Compromised in Human CD40 Deficiency: A Case Report.

Authors: Maria Pia Cicalese; Jolanda Gerosa; Manuela Baronio; Davide Montin; Francesco Licciardi; Annarosa Soresina; Rosa Maria Dellepiane; Maurizio Miano; Lucia Augusta Baselli; Stefano Volpi; Carlo Dufour; Alessandro Plebani; Alessandro Aiuti; Vassilios Lougaris; Georgia Fousteri
Journal: Front Immunol Date: 2018-08-06 Impact factor: 7.561

Review 4. Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells?

Authors: Antigoni Poultsidi; Yiannis Dimopoulos; Ting-Fang He; Triantafyllos Chavakis; Emmanouil Saloustros; Peter P Lee; Constantinos Petrovas
Journal: Front Immunol Date: 2018-09-27 Impact factor: 7.561

Review 5. Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation-Lessons From Rheumatoid Arthritis.

Authors: Karine Chemin; Christina Gerstner; Vivianne Malmström
Journal: Front Immunol Date: 2019-03-12 Impact factor: 7.561

PD-1^hiCXCR5^-CD4⁺ T_FH Cells Play Defense in Cancer and Offense in Arthritis.

1. Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity.

Review 2. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy.

3. Circulating Follicular Helper and Follicular Regulatory T Cells Are Severely Compromised in Human CD40 Deficiency: A Case Report.

Review 4. Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells?

Review 5. Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation-Lessons From Rheumatoid Arthritis.

6. The Anti-Inflammatory Effects of CXCR5 in the Mice Retina following Ischemia-Reperfusion Injury.

Review 7. Emerging Complexity in CD4⁺T Lineage Programming and Its Implications in Colorectal Cancer.

8. PD-1⁺CXCR5^-CD4⁺ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma.

PD-1hiCXCR5-CD4+ TFH Cells Play Defense in Cancer and Offense in Arthritis.

1. Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity.

Review 2. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy.

3. Circulating Follicular Helper and Follicular Regulatory T Cells Are Severely Compromised in Human CD40 Deficiency: A Case Report.

Review 4. Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells?

Review 5. Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation-Lessons From Rheumatoid Arthritis.

6. The Anti-Inflammatory Effects of CXCR5 in the Mice Retina following Ischemia-Reperfusion Injury.

Review 7. Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal Cancer.

8. PD-1+CXCR5-CD4+ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma.

PD-1^hiCXCR5^-CD4⁺ T_FH Cells Play Defense in Cancer and Offense in Arthritis.

Review 7. Emerging Complexity in CD4⁺T Lineage Programming and Its Implications in Colorectal Cancer.

8. PD-1⁺CXCR5^-CD4⁺ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma.