Ha-Jung Kim1, Seung-Hwa Lee2, Han-Na Go2, Jae-Rin Ahn2, Hye-Jung Kim3, Soo-Jong Hong4. 1. Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea. 2. Asan Institute for Life Sciences, College of Medicine, University of Ulsan, Seoul, South Korea. 3. Food R&D center, Samyang Corp, Seongnam 13488, South Korea. 4. Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea; Environmental Health Center, Asan Medical Center, Seoul, South Korea. Electronic address: sjhong@amc.seoul.kr.
Abstract
BACKGROUND: Atopic dermatitis (AD) is recently increasing among populations, but the underlying mechanisms remain controversial. Interactions between the gut microbiota and mucosal immunity are considered to be a crucial etiology. Fructooligosaccharide (FOS), prebiotics have been reported as activators of the gut microbiota. OBJECTIVE: The aim of this study was to investigate the effects of kestose, the smallest FOS and FOS on atopic dermatitis in mice. METHODS: An AD mouse model was developed by (ovalbumin) epidermal sensitization using BALB/c mice. Kestose (1%, 5%, and 10%) or FOS (5%, positive control) was orally administered throughout the study. RESULTS: In comparison with the values observed for the control AD mice, transepidermal water loss (TEWL), clinical score, and skin inflammation on histopathology were significantly decreased by the oral administration of kestose. Total IgE, thymic stromal lymphopoietin (TSLP) in skin, and IL-4 were also suppressed by this administration. In addition, the population of CD4+Foxp3+ cells in mesenteric lymph nodes (MLNs) and acetate concentrations in feces were significantly increased by kestose treatment. CONCLUSIONS: These findings suggest that kestose activates the gut immune system to induce the tolerance against allergic skin inflammations in AD.
BACKGROUND:Atopic dermatitis (AD) is recently increasing among populations, but the underlying mechanisms remain controversial. Interactions between the gut microbiota and mucosal immunity are considered to be a crucial etiology. Fructooligosaccharide (FOS), prebiotics have been reported as activators of the gut microbiota. OBJECTIVE: The aim of this study was to investigate the effects of kestose, the smallest FOS and FOS on atopic dermatitis in mice. METHODS: An ADmouse model was developed by (ovalbumin) epidermal sensitization using BALB/c mice. Kestose (1%, 5%, and 10%) or FOS (5%, positive control) was orally administered throughout the study. RESULTS: In comparison with the values observed for the control ADmice, transepidermal water loss (TEWL), clinical score, and skin inflammation on histopathology were significantly decreased by the oral administration of kestose. Total IgE, thymic stromal lymphopoietin (TSLP) in skin, and IL-4 were also suppressed by this administration. In addition, the population of CD4+Foxp3+ cells in mesenteric lymph nodes (MLNs) and acetate concentrations in feces were significantly increased by kestose treatment. CONCLUSIONS: These findings suggest that kestose activates the gut immune system to induce the tolerance against allergic skin inflammations in AD.
Authors: Mi Jin Kang; So Yeon Lee; Yoon Mee Park; Bong Soo Kim; Min Jung Lee; Jeong Hyun Kim; Seonmi Jeong; Seung Hwa Lee; Min Jee Park; Eun Sang Rhee; Sungsu Jung; Jisun Yoon; Hyun Ju Cho; Eun Lee; Song I Yang; Dong In Suh; Kyung Won Kim; Youn Ho Sheen; Kangmo Ahn; Soo Jong Hong Journal: Allergy Asthma Immunol Res Date: 2021-05 Impact factor: 5.764
Authors: Florisvaldo Gama de Souza; Fábio Fernandes de Araújo; Eduardo Adilson Orlando; Fernando Morais Rodrigues; Davy William Hidalgo Chávez; Juliana Azevedo Lima Pallone; Iramaia Angélica Neri-Numa; Alexandra Christine Helena Frankland Sawaya; Glaucia Maria Pastore Journal: Foods Date: 2022-03-09