Xueqin Xu1, Suzanne L Palmer2, Xiaozhu Lin1, Weixia Li1, Kemin Chen1, Fuhua Yan1, Xiao Li3. 1. Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China. 2. Clinical Radiology and Medicine, Keck Medical Center, University of Southern California, Los Angeles, CA, USA. 3. Department of Nephrology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No. 197, Ruijin ER Road, Shanghai, 200025, China. lixiao-rj@126.com.
Abstract
PURPOSE: To investigate the value of diffusion-weighted imaging (DWI) for assessing histopathologic changes observed in chronic kidney disease (CKD). METHODS: Fifty-two patients with CKD underwent DWI before renal biopsy. The renal apparent diffusion coefficient (ADC) values and histopathologic changes were analyzed. The pathologic changes were scored using a semi-quantitative method (no lesion as 0, mild lesion as 1, moderate lesion as 2, and severe lesion as 3). The relationships between renal histopathologic scores, types, classification, and right renal ADCs were analyzed using ANOVA and Pearson's or Spearman's correlation tests. RESULTS: Negative correlations were found between the right renal ADCs and scores of tubulointerstitial lesions (r = - 0.354, P = 0.012), the severity of tubular atrophy (r = - 0.439, P = 0.002), and the severity of interstitial fibrosis (r = - 0.272, P = 0.049). There were no correlations between the ADCs and scores of glomeruli and peritubular vessel lesions (P > 0.05). There were significant differences among groups based on pathology types (P = 0.009). There was no significant relationship between renal ADCs and the pathologic classification (P > 0.05). CONCLUSIONS: DWI may be helpful to detect tubulointerstitial injury, including tubular atrophy and interstitial fibrosis. DWI may have the potential to serve as an effective auxiliary method to help nephrologists to evaluate patients with CKD.
PURPOSE: To investigate the value of diffusion-weighted imaging (DWI) for assessing histopathologic changes observed in chronic kidney disease (CKD). METHODS: Fifty-two patients with CKD underwent DWI before renal biopsy. The renal apparent diffusion coefficient (ADC) values and histopathologic changes were analyzed. The pathologic changes were scored using a semi-quantitative method (no lesion as 0, mild lesion as 1, moderate lesion as 2, and severe lesion as 3). The relationships between renal histopathologic scores, types, classification, and right renal ADCs were analyzed using ANOVA and Pearson's or Spearman's correlation tests. RESULTS: Negative correlations were found between the right renal ADCs and scores of tubulointerstitial lesions (r = - 0.354, P = 0.012), the severity of tubular atrophy (r = - 0.439, P = 0.002), and the severity of interstitial fibrosis (r = - 0.272, P = 0.049). There were no correlations between the ADCs and scores of glomeruli and peritubular vessel lesions (P > 0.05). There were significant differences among groups based on pathology types (P = 0.009). There was no significant relationship between renal ADCs and the pathologic classification (P > 0.05). CONCLUSIONS: DWI may be helpful to detect tubulointerstitial injury, including tubular atrophy and interstitial fibrosis. DWI may have the potential to serve as an effective auxiliary method to help nephrologists to evaluate patients with CKD.
Authors: Maria A Bedoya; Jeffrey I Berman; Jorge Delgado; Dmitry Khrichenko; Christian A Barrera; Robert H Carson; Kassa Darge Journal: Pediatr Radiol Date: 2019-04-19
Authors: Katarzyna Sułkowska; Piotr Palczewski; Agnieszka Furmańczyk-Zawiska; Agnieszka Perkowska-Ptasińska; Damian Wójcik; Wojciech Szeszkowski; Magdalena Durlik; Marek Gołębiowski; Piotr Małkowski Journal: Ann Transplant Date: 2020-03-03 Impact factor: 1.530