Literature DB >> 29110042

[Acne inversa/hidradenitis suppurativa: A challenge for the future].

R Sabat1,2.   

Abstract

Acne inversa (AI)/hidradenitis suppurativa is a chronic recurrent inflammatory dermatosis with signs of a systemic disease. AI is characterized by typical skin alterations in body areas bearing apocrine glands. The care of the AI patients in Germany is still inadequate. This situation might be significantly improved through the following efforts: (i) shortening of the time between the disease onset and the diagnosis/start of therapy; (ii) the in-depth investigation of AI pathogenesis with the aim of identifying innovative therapeutic targets and blood biomarkers; (iii) establishing a method for quantifying the severity of the disease, which takes into account both the clinical assessment and objective laboratory parameters and the self-assessment of the patient (e.g., Dermatology Life Quality Index [DLQI]); (iv) the elaboration of a clear algorithm for the interdisciplinary treatment of patients, which, in addition to the therapy of skin lesions, also includes lifestyle-modification measures and takes into consideration the systemic character of AI. This article describes the current problems of medical care for AI patients and outlines how we can achieve the predetermined goals.

Entities:  

Keywords:  Biomarkers; IL-22; Metabolic syndrome; Spondyloarthritis; TNF-α

Mesh:

Substances:

Year:  2017        PMID: 29110042     DOI: 10.1007/s00105-017-4079-0

Source DB:  PubMed          Journal:  Hautarzt        ISSN: 0017-8470            Impact factor:   0.751


  27 in total

1.  Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity.

Authors:  C C Zouboulis; T Tzellos; A Kyrgidis; G B E Jemec; F G Bechara; E J Giamarellos-Bourboulis; J R Ingram; T Kanni; I Karagiannidis; A Martorell; Ł Matusiak; A Pinter; E P Prens; D Presser; S Schneider-Burrus; E von Stebut; J C Szepietowski; H H van der Zee; S M Wilden; R Sabat
Journal:  Br J Dermatol       Date:  2017-10-30       Impact factor: 9.302

2.  Diagnostic delay in hidradenitis suppurativa is a global problem.

Authors:  D M Saunte; J Boer; A Stratigos; J C Szepietowski; I Hamzavi; K H Kim; K Zarchi; C Antoniou; L Matusiak; H W Lim; M Williams; H H Kwon; M A Gürer; F Mammadova; A Kaminsky; E Prens; H H van der Zee; V Bettoli; S Zauli; J Hafner; S Lauchli; L E French; H Riad; M El-Domyati; H Abdel-Wahab; B Kirby; G Kelly; P Calderon; V del Marmol; F Benhadou; J Revuz; C C Zouboulis; I Karagiannidis; K Sartorius; L Hagströmer; E McMeniman; N Ong; M Dolenc-Voljc; Z B Mokos; L Borradori; R E Hunger; C Sladden; N Scheinfeld; N Moftah; L Emtestam; J Lapins; N Doss; I Kurokawa; G B E Jemec
Journal:  Br J Dermatol       Date:  2015-11-03       Impact factor: 9.302

3.  Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa.

Authors:  Kerstin Wolk; Katarzyna Warszawska; Conny Hoeflich; Ellen Witte; Sylke Schneider-Burrus; Katrin Witte; Stefanie Kunz; Annette Buss; Hans Joachim Roewert; Markus Krause; Ansgar Lukowsky; Hans-Dieter Volk; Wolfram Sterry; Robert Sabat
Journal:  J Immunol       Date:  2010-12-08       Impact factor: 5.422

4.  Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa.

Authors:  K Wolk; J Wenzel; A Tsaousi; E Witte-Händel; N Babel; C Zelenak; H-D Volk; W Sterry; S Schneider-Burrus; R Sabat
Journal:  Br J Dermatol       Date:  2017-09-19       Impact factor: 9.302

5.  Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β.

Authors:  H H van der Zee; L de Ruiter; D G van den Broecke; W A Dik; J D Laman; E P Prens
Journal:  Br J Dermatol       Date:  2011-05-17       Impact factor: 9.302

6.  Chitinase-3-like Protein 1 (YKL-40): Novel Biomarker of Hidradenitis Suppurativa Disease Activity?

Authors:  Łukasz Matusiak; Joanna Salomon; Danuta Nowicka-Suszko; Andrzej Bieniek; Jacek C Szepietowski
Journal:  Acta Derm Venereol       Date:  2015-07       Impact factor: 4.437

7.  Soluble interleukin-2 receptor serum level is a useful marker of hidradenitis suppurativa clinical staging.

Authors:  Łukasz Matusiak; Andrzej Bieniek; Jacek C Szepietowski
Journal:  Biomarkers       Date:  2009-09       Impact factor: 2.658

8.  Two Phase 3 Trials of Adalimumab for Hidradenitis Suppurativa.

Authors:  Alexa B Kimball; Martin M Okun; David A Williams; Alice B Gottlieb; Kim A Papp; Christos C Zouboulis; April W Armstrong; Francisco Kerdel; Michael H Gold; Seth B Forman; Neil J Korman; Evangelos J Giamarellos-Bourboulis; Jeffrey J Crowley; Charles Lynde; Ziad Reguiai; Errol-Prospero Prens; Eihab Alwawi; Nael M Mostafa; Brett Pinsky; Murali Sundaram; Yihua Gu; Dawn M Carlson; Gregor B E Jemec
Journal:  N Engl J Med       Date:  2016-08-04       Impact factor: 91.245

9.  Increased prevalence of metabolic syndrome in patients with acne inversa.

Authors:  Robert Sabat; Akewit Chanwangpong; Sylke Schneider-Burrus; Deborah Metternich; Georgios Kokolakis; Agata Kurek; Sandra Philipp; Daniela Uribe; Kerstin Wolk; Wolfram Sterry
Journal:  PLoS One       Date:  2012-02-16       Impact factor: 3.240

10.  MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations.

Authors:  Athanasia Tsaousi; Ellen Witte; Katrin Witte; Hans-Joachim Röwert-Huber; Hans-Dieter Volk; Wolfram Sterry; Kerstin Wolk; Sylke Schneider-Burrus; Robert Sabat
Journal:  Mediators Inflamm       Date:  2016-10-23       Impact factor: 4.711

View more
  3 in total

Review 1.  [Acne inversa/hidradenitis suppurativa: An update].

Authors:  R Sabat; A Tsaousi; J Rossbacher; H Kurzen; T Fadai; U Schwichtenberg; S Schneider-Burrus; G Kokolakis; K Wolk
Journal:  Hautarzt       Date:  2017-12       Impact factor: 0.751

Review 2.  [Surgical treatment options for hidradenitis suppurativa/acne inversa].

Authors:  L Scholl; S Hessam; S Reitenbach; F G Bechara
Journal:  Hautarzt       Date:  2018-02       Impact factor: 0.751

Review 3.  [Hidradenitis suppurativa /acne inversa-surgical options, reconstruction and combinations with drug therapies-an update].

Authors:  P Cramer; S Schneider-Burrus; M Kovács; L Scholl; M Podda; F G Bechara
Journal:  Hautarzt       Date:  2021-07-06       Impact factor: 0.751

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.