Monica J Mahajani1, Varsha A Jadhao2, Pooja S Wankhade3, Emmanuel Samson4, Vishwas D Acharya5, Pawankumar D Tekale6. 1. Department of Periodontics, Dr. Hedgewar Smruti Rugna Seva Mandal Dental College & Hospital, Hingoli, Maharashtra, India. 2. Department of Dentistry, Government Medical College & Hospital, Akola Maharashtra, India. 3. Department of Oral Medicine and Radiology, VYWS, Amravati's Dental College & Hospital, Amravati Maharashtra, India. 4. Department of Conservative and Endodontics, Dr. Hedgewar Smruti Rugna Seva Mandal Dental College & Hospital, Hingoli Maharashtra, India. 5. Department of Oral Medicine and Radiology, Dr. Hedgewar Smruti Rugna Seva Mandal Dental College & Hospital, Hingoli Maharashtra, India. 6. Department of Orthodontics, Dr. Rajesh Ramdasji Kambe Dental College & Hospital, Akola, Maharashtra, India, Phone: +919970879100 e-mail: pawan0804@gmail.com.
Abstract
AIM: The incidence and progression of the periodontal disease depend on periodontal microflora and the multifaceted response of the host, and these interactions are mediated by cytokines and chemokines. Interleukin-18 (IL-18) is a proinflammatory cytokine of the IL-1 superfamily. The aim of the present study was the assessment of the periodontal therapy in IL-18 level in periodontal disease and health. MATERIALS AND METHODS: Based on clinical attachment loss (CAL), probing pocket depth (PPD), gingival index (GI), and plaque index (PI) patients were divided into three groups: Group I with healthy patients, group II with chronic periodontitis, and group III with posttreatment patients having periodontitis. RESULTS: Mean PI, PPD, CAL, and gingival crevicular fluid (GCF) volume were significantly higher in groups II and III compared with group I. However, there were no significant differences between GI in groups I, II, and III. The total amount of IL-18 in GCF was significantly higher in group II when compared with groups I and III (p < 0.05). CONCLUSION: The present study confirmed that the IL-18 level in GCF was lower in healthy patients, higher in periodontally involved patients, and reduced at baseline, 3 and 6 weeks after nonsurgical periodontal therapy. CLINICAL SIGNIFICANCE: The IL-18 might be hypothetically beneficial in distinguishing health from disease and monitoring periodontal disease activity.
AIM: The incidence and progression of the periodontal disease depend on periodontal microflora and the multifaceted response of the host, and these interactions are mediated by cytokines and chemokines. Interleukin-18 (IL-18) is a proinflammatory cytokine of the IL-1 superfamily. The aim of the present study was the assessment of the periodontal therapy in IL-18 level in periodontal disease and health. MATERIALS AND METHODS: Based on clinical attachment loss (CAL), probing pocket depth (PPD), gingival index (GI), and plaque index (PI) patients were divided into three groups: Group I with healthy patients, group II with chronic periodontitis, and group III with posttreatment patients having periodontitis. RESULTS: Mean PI, PPD, CAL, and gingival crevicular fluid (GCF) volume were significantly higher in groups II and III compared with group I. However, there were no significant differences between GI in groups I, II, and III. The total amount of IL-18 in GCF was significantly higher in group II when compared with groups I and III (p < 0.05). CONCLUSION: The present study confirmed that the IL-18 level in GCF was lower in healthy patients, higher in periodontally involved patients, and reduced at baseline, 3 and 6 weeks after nonsurgical periodontal therapy. CLINICAL SIGNIFICANCE: The IL-18 might be hypothetically beneficial in distinguishing health from disease and monitoring periodontal disease activity.