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Literature DB >> 29108898

Thymidine phosphorylase: A potential new target for treating cardiovascular disease.

Abstract

We recently found that thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of TYMP. Since platelet-mediated clot formation is a key event in several fatal diseases, such as myocardial infarction, stroke and pulmonary embolism, understanding TYMP in depth may lead to uncovering novel mechanisms in the development of cardiovascular diseases. Targeting TYMP may become a novel therapeutic for cardiovascular disorders. In this review article, we summarize the discovery of TYMP and the potential molecular mechanisms of TYMP involved in the development of various diseases, especially cardiovascular diseases. We also offer insights regarding future studies exploring the role of TYMP in the development of cardiovascular disease as well as in therapy.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Cancer; Platelets; Thrombosis; Thymidine phosphorylase

Mesh：

Substances：

Year: 2017 PMID： 29108898 PMCID： PMC5856583 DOI： 10.1016/j.tcm.2017.10.003

Source DB: PubMed Journal: Trends Cardiovasc Med ISSN： 1050-1738 Impact factor: 6.677

159 in total

1. The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue.

Authors: M FRIEDKIN; D ROBERTS
Journal: J Biol Chem Date: 1954-03 Impact factor: 5.157

2. Induction of platelet derived-endothelial cell growth factor in the brain after ischemia.

Authors: T Hayashi; X Q Wang; H Z Zhang; K Deguchi; S Nagotani; Y Sehara; A Tsuchiya; M Nagai; M Shoji; K Abe
Journal: Neurol Res Date: 2007-07 Impact factor: 2.448

3. Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements.

Authors: J R Woodgett; K L Gould; T Hunter
Journal: Eur J Biochem Date: 1986-11-17

4. Thymidine phosphorylase expression in normal and hyperplastic endometrium.

Authors: E Sivridis; A Giatromanolaki; M I Koukourakis; R Bicknell; A L Harris; K C Gatter
Journal: J Clin Pathol Date: 2000-09 Impact factor: 3.411

5. Thymidine phosphorylase gene transfer inhibits vascular smooth muscle cell proliferation by upregulating heme oxygenase-1 and p27KIP1.

Authors: Wei Li; Kuniyoshi Tanaka; Koichi Morioka; Takahiko Uesaka; Narihisa Yamada; Atsushi Takamori; Mitsuteru Handa; Sawaka Tanabe; Akio Ihaya
Journal: Arterioscler Thromb Vasc Biol Date: 2005-05-05 Impact factor: 8.311

6. Purification and properties of an endothelial cell growth factor from human platelets.

Authors: K Miyazono; T Okabe; A Urabe; F Takaku; C H Heldin
Journal: J Biol Chem Date: 1987-03-25 Impact factor: 5.157

7. Purification of thymidine phosphorylase from human amniochorion.

Authors: J Kubilus; L D Lee; H P Baden
Journal: Biochim Biophys Acta Date: 1978-11-10

8. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures.

Authors: Giordano Pula; Ursula Mayr; Colin Evans; Marianna Prokopi; Dina S Vara; Xiaoke Yin; Zoe Astroulakis; Qingzhong Xiao; Jonathan Hill; Qingbo Xu; Manuel Mayr
Journal: Circ Res Date: 2008-11-20 Impact factor: 17.367

9. Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.

Authors: S B Fox; A Moghaddam; M Westwood; H Turley; R Bicknell; K C Gatter; A L Harris
Journal: J Pathol Date: 1995-06 Impact factor: 7.996

10. Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.

Authors: Eirini Mitsiki; Anastassios C Papageorgiou; Shalini Iyer; Nethaji Thiyagarajan; Steven H Prior; Darrell Sleep; Chris Finnis; K Ravi Acharya
Journal: Biochem Biophys Res Commun Date: 2009-06-23 Impact factor: 3.575

19 in total

1. Quantitative analysis of differentially expressed proteins in psoriasis vulgaris using tandem mass tags and parallel reaction monitoring.

Authors: Yu Li; Peng Lin; Siyao Wang; Shuang Li; Rui Wang; Lin Yang; Hongmei Wang
Journal: Clin Proteomics Date: 2020-08-12 Impact factor: 3.988

2. Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants with Congenital Heart Disease.

Authors: Jelena Klawitter; Jesse Davidson; Evan Pagano; Benjamin Frank; James Jaggers; Mark Twite; Tracy T Urban
Journal: Congenit Heart Dis Date: 2020-09-07 Impact factor: 2.007

3. Targeting Thymidine Phosphorylase With Tipiracil Hydrochloride Attenuates Thrombosis Without Increasing Risk of Bleeding in Mice.

Authors: Adam Belcher; Abu Hasanat Md Zulfiker; Oliver Qiyue Li; Hong Yue; Anirban Sen Gupta; Wei Li
Journal: Arterioscler Thromb Vasc Biol Date: 2020-12-10 Impact factor: 8.311

Thymidine phosphorylase: A potential new target for treating cardiovascular disease.

1. The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue.

2. Induction of platelet derived-endothelial cell growth factor in the brain after ischemia.

3. Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements.

4. Thymidine phosphorylase expression in normal and hyperplastic endometrium.

5. Thymidine phosphorylase gene transfer inhibits vascular smooth muscle cell proliferation by upregulating heme oxygenase-1 and p27KIP1.

6. Purification and properties of an endothelial cell growth factor from human platelets.

7. Purification of thymidine phosphorylase from human amniochorion.

8. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures.

9. Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.

10. Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.

1. Quantitative analysis of differentially expressed proteins in psoriasis vulgaris using tandem mass tags and parallel reaction monitoring.

2. Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants with Congenital Heart Disease.

3. Targeting Thymidine Phosphorylase With Tipiracil Hydrochloride Attenuates Thrombosis Without Increasing Risk of Bleeding in Mice.

4. The proteomic characterization of the peritumor microenvironment in human hepatocellular carcinoma.

Review 5. Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications.

Review 6. Mitochondrial Neurogastrointestinal Encephalomyopathy: Into the Fourth Decade, What We Have Learned So Far.

7. Thymidine Phosphorylase Is Increased in COVID-19 Patients in an Acuity-Dependent Manner.

8. A cluster of metabolism-related genes predict prognosis and progression of clear cell renal cell carcinoma.

9. New Candidates for Biomarkers and Drug Targets of Ischemic Stroke-A First Dynamic LC-MS Human Serum Proteomic Study.

10. Identification of Key Pathways and Genes in Obesity Using Bioinformatics Analysis and Molecular Docking Studies.