| Literature DB >> 29107344 |
Abstract
Artificial chromosomes are useful in making functional vectors for very large genes, studying chromosome physiology, and modeling chromosomal disorders. Shinohara et al. have succeeded for the first time in creating transchromosomic mice by manipulating spermatogonial stem cells (SSCs), which exhibited superior chromosomal stability compared with embryonic stem cells (ESCs).Entities:
Keywords: artificial chromosomes; karyotype; spermatogenesis; spermatogonia; stem cells
Mesh:
Year: 2017 PMID: 29107344 PMCID: PMC5701830 DOI: 10.1016/j.tig.2017.10.003
Source DB: PubMed Journal: Trends Genet ISSN: 0168-9525 Impact factor: 11.639