Adriana Seelye1, Nora Mattek2, Nicole Sharma2, Thomas Riley2, Johanna Austin2, Katherine Wild2, Hiroko H Dodge3, Emily Lore2, Jeffrey Kaye4. 1. Department of Neurology, Oregon Health & Science University, Portland, OR, USA; Oregon Center for Aging & Technology, Oregon Health & Science University, Portland, OR, USA; Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA. Electronic address: seelyea@ohsu.edu. 2. Department of Neurology, Oregon Health & Science University, Portland, OR, USA; Oregon Center for Aging & Technology, Oregon Health & Science University, Portland, OR, USA. 3. Department of Neurology, Oregon Health & Science University, Portland, OR, USA; Oregon Center for Aging & Technology, Oregon Health & Science University, Portland, OR, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, USA. 4. Department of Neurology, Oregon Health & Science University, Portland, OR, USA; Oregon Center for Aging & Technology, Oregon Health & Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Abstract
INTRODUCTION: Subtle changes in instrumental activities of daily living often accompany the onset of mild cognitive impairment (MCI) but are difficult to measure using conventional tests. METHODS: Weekly online survey metadata metrics, annual neuropsychological tests, and an instrumental activity of daily living questionnaire were examined in 110 healthy older adults with intact cognition (mean age = 85 years) followed up for up to 3.6 years; 29 transitioned to MCI during study follow-up. RESULTS: In the baseline period, incident MCI participants completed their weekly surveys 1.4 hours later in the day than stable cognitively intact participants, P = .03, d = 0.47. Significant associations were found between earlier survey start time of day and higher memory (r = -0.34; P < .001) and visuospatial test scores (r = -0.37; P < .0001). Longitudinally, incident MCI participants showed an increase in survey completion time by 3 seconds per month for more than the year before diagnosis compared with stable cognitively intact participants (β = 0.12, SE = 0.04, t = 2.8; P = .006). DISCUSSION: Weekly online survey metadata allowed for detection of changes in everyday cognition before transition to MCI. Published by Elsevier Inc.
INTRODUCTION: Subtle changes in instrumental activities of daily living often accompany the onset of mild cognitive impairment (MCI) but are difficult to measure using conventional tests. METHODS: Weekly online survey metadata metrics, annual neuropsychological tests, and an instrumental activity of daily living questionnaire were examined in 110 healthy older adults with intact cognition (mean age = 85 years) followed up for up to 3.6 years; 29 transitioned to MCI during study follow-up. RESULTS: In the baseline period, incident MCIparticipants completed their weekly surveys 1.4 hours later in the day than stable cognitively intact participants, P = .03, d = 0.47. Significant associations were found between earlier survey start time of day and higher memory (r = -0.34; P < .001) and visuospatial test scores (r = -0.37; P < .0001). Longitudinally, incident MCIparticipants showed an increase in survey completion time by 3 seconds per month for more than the year before diagnosis compared with stable cognitively intact participants (β = 0.12, SE = 0.04, t = 2.8; P = .006). DISCUSSION: Weekly online survey metadata allowed for detection of changes in everyday cognition before transition to MCI. Published by Elsevier Inc.
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